Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: Altered working memory and bold response

Thomas W. McAllister, Laura A. Flashman, Brenna McDonald, Richard B. Ferrell, Tor D. Tosteson, Norman N. Yanofsky, Margaret R. Grove, Andrew Saykin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume23
Issue number3
DOIs
StatePublished - 2011

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Brain Concussion
Bromocriptine
Short-Term Memory
Dopamine
Catecholamines
Placebos
Magnetic Resonance Imaging
Wounds and Injuries

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury : Altered working memory and bold response. / McAllister, Thomas W.; Flashman, Laura A.; McDonald, Brenna; Ferrell, Richard B.; Tosteson, Tor D.; Yanofsky, Norman N.; Grove, Margaret R.; Saykin, Andrew.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 23, No. 3, 2011, p. 277-286.

Research output: Contribution to journalArticle

McAllister, Thomas W. ; Flashman, Laura A. ; McDonald, Brenna ; Ferrell, Richard B. ; Tosteson, Tor D. ; Yanofsky, Norman N. ; Grove, Margaret R. ; Saykin, Andrew. / Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury : Altered working memory and bold response. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2011 ; Vol. 23, No. 3. pp. 277-286.
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