Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: Altered working memory and bold response

Thomas W. McAllister, Laura A. Flashman, Brenna C. Mcdonald, Richard B. Ferrell, Tor D. Tosteson, Norman N. Yanofsky, Margaret R. Grove, Andrew J. Saykin

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume23
Issue number3
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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