Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury

Altered working memory and bold response

Thomas W. McAllister, Laura A. Flashman, Brenna McDonald, Richard B. Ferrell, Tor D. Tosteson, Norman N. Yanofsky, Margaret R. Grove, Andrew Saykin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume23
Issue number3
DOIs
StatePublished - 2011

Fingerprint

Brain Concussion
Bromocriptine
Short-Term Memory
Dopamine
Catecholamines
Placebos
Magnetic Resonance Imaging
Wounds and Injuries

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury : Altered working memory and bold response. / McAllister, Thomas W.; Flashman, Laura A.; McDonald, Brenna; Ferrell, Richard B.; Tosteson, Tor D.; Yanofsky, Norman N.; Grove, Margaret R.; Saykin, Andrew.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 23, No. 3, 2011, p. 277-286.

Research output: Contribution to journalArticle

McAllister, Thomas W. ; Flashman, Laura A. ; McDonald, Brenna ; Ferrell, Richard B. ; Tosteson, Tor D. ; Yanofsky, Norman N. ; Grove, Margaret R. ; Saykin, Andrew. / Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury : Altered working memory and bold response. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2011 ; Vol. 23, No. 3. pp. 277-286.
@article{41411760e9284b8fb23593e39fc5fa8c,
title = "Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury: Altered working memory and bold response",
abstract = "Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.",
author = "McAllister, {Thomas W.} and Flashman, {Laura A.} and Brenna McDonald and Ferrell, {Richard B.} and Tosteson, {Tor D.} and Yanofsky, {Norman N.} and Grove, {Margaret R.} and Andrew Saykin",
year = "2011",
doi = "10.1176/appi.neuropsych.23.3.277",
language = "English",
volume = "23",
pages = "277--286",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "3",

}

TY - JOUR

T1 - Dopaminergic challenge with bromocriptine one month after mild traumatic brain injury

T2 - Altered working memory and bold response

AU - McAllister, Thomas W.

AU - Flashman, Laura A.

AU - McDonald, Brenna

AU - Ferrell, Richard B.

AU - Tosteson, Tor D.

AU - Yanofsky, Norman N.

AU - Grove, Margaret R.

AU - Saykin, Andrew

PY - 2011

Y1 - 2011

N2 - Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

AB - Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

UR - http://www.scopus.com/inward/record.url?scp=80054970823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054970823&partnerID=8YFLogxK

U2 - 10.1176/appi.neuropsych.23.3.277

DO - 10.1176/appi.neuropsych.23.3.277

M3 - Article

VL - 23

SP - 277

EP - 286

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 3

ER -