Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.

S. P. Sivam, G. R. Breese, T. C. Napier, R. A. Mueller, J. S. Hong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Dopaminergic denervation by 6-hydroxydopamine (6-OHDA) increased proenkephalin-A gene expression in the striatum as evidenced by increases in the levels of Met5-enkephalin (ME), precursor and preproenkephalin mRNA (PE-mRNA). This and other lines of evidence support the hypothesis that nigrostriatal dopamine input is inhibitory to striatal enkephalin neurons and that the removal of this inhibitory influence leads to an acceleration of ME biosynthesis. These findings suggest that the enkephalin system may be associated with the progression of adaptive changes subsequent to dopaminergic dysfunction in basal ganglia.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalNIDA research monograph
Volume75
StatePublished - 1986

Fingerprint

Enkephalins
Basal Ganglia
Gene Expression
Oxidopamine
Corpus Striatum
RNA Precursors
Denervation
Dopamine
Neurons
proenkephalin

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Sivam, S. P., Breese, G. R., Napier, T. C., Mueller, R. A., & Hong, J. S. (1986). Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia. NIDA research monograph, 75, 389-392.

Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia. / Sivam, S. P.; Breese, G. R.; Napier, T. C.; Mueller, R. A.; Hong, J. S.

In: NIDA research monograph, Vol. 75, 1986, p. 389-392.

Research output: Contribution to journalArticle

Sivam, SP, Breese, GR, Napier, TC, Mueller, RA & Hong, JS 1986, 'Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia.', NIDA research monograph, vol. 75, pp. 389-392.
Sivam, S. P. ; Breese, G. R. ; Napier, T. C. ; Mueller, R. A. ; Hong, J. S. / Dopaminergic regulation of proenkephalin-A gene expression in the basal ganglia. In: NIDA research monograph. 1986 ; Vol. 75. pp. 389-392.
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