Doppler imaging of intracellular dynamics in clinical cancer chemotherapy

David D. Nolte, John J. Turek, Daniela E. Matei, Shadia Jalal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biodynamic imaging of chemotherapy response in ex vivo patient biopsies measures changes of intracellular dynamics in response to applied therapeutics. The technique is based on near-IR low-coherence digital holography of Dopplerbroadened light scattering from intracellular dynamics. Three clinical trials of this diagnostic biophotonic technology are nearing completion in esophageal cancer, epithelial ovarian cancer and breast cancer.

Original languageEnglish (US)
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
StatePublished - Jan 1 2019
Externally publishedYes
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: Jun 23 2019Jun 25 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
CountryGermany
CityMunich
Period6/23/196/25/19

Fingerprint

Chemotherapy
chemotherapy
Holography
cancer
Breast Neoplasms
Imaging techniques
Drug Therapy
Biopsy
Esophageal Neoplasms
Light scattering
biodynamics
Neoplasms
Clinical Trials
Technology
breast
holography
light scattering
Therapeutics
Ovarian epithelial cancer
Dynamic Light Scattering

Keywords

  • Clinical trial
  • Digital holography
  • Dynamic light Scattering
  • Interferometry
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Nolte, D. D., Turek, J. J., Matei, D. E., & Jalal, S. (2019). Doppler imaging of intracellular dynamics in clinical cancer chemotherapy. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II [110730J] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2527073

Doppler imaging of intracellular dynamics in clinical cancer chemotherapy. / Nolte, David D.; Turek, John J.; Matei, Daniela E.; Jalal, Shadia.

Clinical and Preclinical Optical Diagnostics II. ed. / J. Quincy Brown; Ton G. van Leeuwen. SPIE, 2019. 110730J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nolte, DD, Turek, JJ, Matei, DE & Jalal, S 2019, Doppler imaging of intracellular dynamics in clinical cancer chemotherapy. in JQ Brown & TG van Leeuwen (eds), Clinical and Preclinical Optical Diagnostics II., 110730J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11073, SPIE, Clinical and Preclinical Optical Diagnostics II 2019, Munich, Germany, 6/23/19. https://doi.org/10.1117/12.2527073
Nolte DD, Turek JJ, Matei DE, Jalal S. Doppler imaging of intracellular dynamics in clinical cancer chemotherapy. In Brown JQ, van Leeuwen TG, editors, Clinical and Preclinical Optical Diagnostics II. SPIE. 2019. 110730J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2527073
Nolte, David D. ; Turek, John J. ; Matei, Daniela E. ; Jalal, Shadia. / Doppler imaging of intracellular dynamics in clinical cancer chemotherapy. Clinical and Preclinical Optical Diagnostics II. editor / J. Quincy Brown ; Ton G. van Leeuwen. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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