Dorsomedial hypothalamic GABA regulates anxiety in the social interaction test

A. Shekhar, J. S. Katner

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Blockade of GABAA function in the region of the dorsomedial hypothalamus (DMH) of rats is known to elicit a constellation of physiologic responses including increases in heart rate (HR), mean arterial blood pressure (BP), respiratory rate and plasma catecholamine levels, as well as behavioral responses such as increases in locomotor activity and anxiogenic-like effects as measured in a conflict test and the elevated plus-maze test. The aim of the present study was to test the effects of microinjecting GABAA antagonists bicuculline methiodide (BMI) and picrotoxin, as well as the GABAA agonist muscimol, into the DMH of rats placed in the social interaction (SI) test. Muscimol decreased HR and BP but increased SI, whereas the GABA antagonists increased HR and BP but decreased SI time. Blocking the HR changes elicited by GABAergic drugs injected into the DMH with systemic injections of atenolol and atropine methylbromide did not block their effects on SI.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume50
Issue number2
DOIs
StatePublished - Feb 1995

Keywords

  • Anxiolytics
  • Benzodiazepines
  • Bicuculline
  • Blood pressure
  • Heart rate
  • Muscimol
  • Picrotoxin
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Pharmacology
  • Toxicology

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