Abstract
Purpose: The aim of this study was to investigate the haemodynamic effects of topical dorzolamide treatment in eyes with newly detected and previously untreated glaucoma. Methods: Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. Ocular blood flow was investigated at baseline and on therapy using colour Doppler imaging of the retrobulbar vessels and scanning laser ophthalmoscope fluorescein angiograms of the retinal circulation. Results: None of the flow parameters, retrobulbar or retinal, changed significantly on therapy when the results were analysed with the Bonferroni method. Analysis with non-simultaneous tests also failed to reveal any significant changes either in retrobulbar flow velocities in the central retinal artery, ophthalmic artery or in the short posterior ciliary arteries, or in the retinal parameters (arm-retina time, arteriovenous passage time, mean dye velocity or macular capillary velocity), while capillary velocities at the optic disc decreased significantly in the dorzolamide group (P = 0.03). Intraocular pressure reduction was significantly more pronounced in the dorzolamide group (P = 0.002), with - 4.8 ± 2.9 mmHg (P < 0.0001) versus - 1.8 ± 3.0 mmHg in the placebo group (P = 0.006). Conclusions: The present study indicated no measurable vascular effects from topical dorzolamide treatment in previously untreated glaucoma eyes.
| Original language | English |
|---|---|
| Pages (from-to) | 176-182 |
| Number of pages | 7 |
| Journal | Acta Ophthalmologica Scandinavica |
| Volume | 80 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Blood flow
- Carbonic anhydrase inhibitors
- Glaucoma
- Glaucoma medications
- Ophthalmic artery
- Optic nerve
- Retinal artery
- Sulfonamides
- Thiophenes
ASJC Scopus subject areas
- Ophthalmology
Cite this
Dorzolamide and ocular blood flow in previously untreated glaucoma patients : A controlled double-masked study. / Bergstrand, Ingar C.; Heijl, Anders; Harris, Alon.
In: Acta Ophthalmologica Scandinavica, Vol. 80, No. 2, 2002, p. 176-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dorzolamide and ocular blood flow in previously untreated glaucoma patients
T2 - A controlled double-masked study
AU - Bergstrand, Ingar C.
AU - Heijl, Anders
AU - Harris, Alon
PY - 2002
Y1 - 2002
N2 - Purpose: The aim of this study was to investigate the haemodynamic effects of topical dorzolamide treatment in eyes with newly detected and previously untreated glaucoma. Methods: Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. Ocular blood flow was investigated at baseline and on therapy using colour Doppler imaging of the retrobulbar vessels and scanning laser ophthalmoscope fluorescein angiograms of the retinal circulation. Results: None of the flow parameters, retrobulbar or retinal, changed significantly on therapy when the results were analysed with the Bonferroni method. Analysis with non-simultaneous tests also failed to reveal any significant changes either in retrobulbar flow velocities in the central retinal artery, ophthalmic artery or in the short posterior ciliary arteries, or in the retinal parameters (arm-retina time, arteriovenous passage time, mean dye velocity or macular capillary velocity), while capillary velocities at the optic disc decreased significantly in the dorzolamide group (P = 0.03). Intraocular pressure reduction was significantly more pronounced in the dorzolamide group (P = 0.002), with - 4.8 ± 2.9 mmHg (P < 0.0001) versus - 1.8 ± 3.0 mmHg in the placebo group (P = 0.006). Conclusions: The present study indicated no measurable vascular effects from topical dorzolamide treatment in previously untreated glaucoma eyes.
AB - Purpose: The aim of this study was to investigate the haemodynamic effects of topical dorzolamide treatment in eyes with newly detected and previously untreated glaucoma. Methods: Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. Ocular blood flow was investigated at baseline and on therapy using colour Doppler imaging of the retrobulbar vessels and scanning laser ophthalmoscope fluorescein angiograms of the retinal circulation. Results: None of the flow parameters, retrobulbar or retinal, changed significantly on therapy when the results were analysed with the Bonferroni method. Analysis with non-simultaneous tests also failed to reveal any significant changes either in retrobulbar flow velocities in the central retinal artery, ophthalmic artery or in the short posterior ciliary arteries, or in the retinal parameters (arm-retina time, arteriovenous passage time, mean dye velocity or macular capillary velocity), while capillary velocities at the optic disc decreased significantly in the dorzolamide group (P = 0.03). Intraocular pressure reduction was significantly more pronounced in the dorzolamide group (P = 0.002), with - 4.8 ± 2.9 mmHg (P < 0.0001) versus - 1.8 ± 3.0 mmHg in the placebo group (P = 0.006). Conclusions: The present study indicated no measurable vascular effects from topical dorzolamide treatment in previously untreated glaucoma eyes.
KW - Blood flow
KW - Carbonic anhydrase inhibitors
KW - Glaucoma
KW - Glaucoma medications
KW - Ophthalmic artery
KW - Optic nerve
KW - Retinal artery
KW - Sulfonamides
KW - Thiophenes
UR - http://www.scopus.com/inward/record.url?scp=0036123663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036123663&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0420.2002.800211.x
DO - 10.1034/j.1600-0420.2002.800211.x
M3 - Article
C2 - 11952485
AN - SCOPUS:0036123663
VL - 80
SP - 176
EP - 182
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 2
ER -