Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension

S. Traustason, S. H. Hardarson, M. S. Gottfredsdottir, T. Eysteinsson, R. A. Karlsson, E. Stefánsson, Alon Harris

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aims: To examine whether the addition of dorzolamide to timolol monotherapy influences oxygen saturation in the human retina. Methods: Non-invasive spectrophotometric retinal oximetry was used to measure oxygen saturation in retinal vessels. Twenty patients with open-angle glaucoma (11) and ocular hypertension (9) were recruited. The patients were randomised into receiving timolol monotherapy or dorzolamide-timolol combination for an 8-month test period, followed by a second test period, before which the patients switched treatments. Oximetry measurements were performed at 2-month intervals during each period. Of the 20 patients, 13 followed the study protocol into the second test period, and 10 managed all study visits. Results: The oxygen saturation in retinal vessels was stable within the test periods. The mean arteriolar saturation was 96 (2)% (mean (SD)) during timolol monotherapy and 97 (2)% during dorzolamide-timolol combination therapy (p=0.17, all patients pooled, n=13). Corresponding values in venules were 66 (5)% during timolol monotherapy and 65 (6)% during dorzolamide-timolol therapy (p=0.13). Patients who started on dorzolamide-timolol combination showed a significant reduction in arteriolar (98 (2)% to 95 (2)%, p<0.01) and venular saturation (69 (5)% to 66 (6)%, p<0.05) when changing to timolol monotherapy. Conclusion: Adding dorzolamide to timolol monotherapy has a minimal effect, but going from dorzolamide-timolol combination to timolol alone lowered arteriolar and venular oxygen saturation. The retinal oxygen saturation measurements show a high degree of stability over an extended period of time. Previous studies have suggested increased retinal and optic nerve blood flow with dorzolamide. Unchanged oxygen saturation and increased blood flow would indicate increased oxygen delivery to the retina.

Original languageEnglish
Pages (from-to)1064-1067
Number of pages4
JournalBritish Journal of Ophthalmology
Volume93
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Timolol
Retinal Vessels
Ocular Hypertension
dorzolamide
Glaucoma
Oxygen
Oximetry
Retina
Venules
dorzolamide-timolol combination
Open Angle Glaucoma
Optic Nerve
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Traustason, S., Hardarson, S. H., Gottfredsdottir, M. S., Eysteinsson, T., Karlsson, R. A., Stefánsson, E., & Harris, A. (2009). Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension. British Journal of Ophthalmology, 93(8), 1064-1067. https://doi.org/10.1136/bjo.2008.148460

Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension. / Traustason, S.; Hardarson, S. H.; Gottfredsdottir, M. S.; Eysteinsson, T.; Karlsson, R. A.; Stefánsson, E.; Harris, Alon.

In: British Journal of Ophthalmology, Vol. 93, No. 8, 08.2009, p. 1064-1067.

Research output: Contribution to journalArticle

Traustason, S, Hardarson, SH, Gottfredsdottir, MS, Eysteinsson, T, Karlsson, RA, Stefánsson, E & Harris, A 2009, 'Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension', British Journal of Ophthalmology, vol. 93, no. 8, pp. 1064-1067. https://doi.org/10.1136/bjo.2008.148460
Traustason S, Hardarson SH, Gottfredsdottir MS, Eysteinsson T, Karlsson RA, Stefánsson E et al. Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension. British Journal of Ophthalmology. 2009 Aug;93(8):1064-1067. https://doi.org/10.1136/bjo.2008.148460
Traustason, S. ; Hardarson, S. H. ; Gottfredsdottir, M. S. ; Eysteinsson, T. ; Karlsson, R. A. ; Stefánsson, E. ; Harris, Alon. / Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension. In: British Journal of Ophthalmology. 2009 ; Vol. 93, No. 8. pp. 1064-1067.
@article{7699a9725e2148c7986af9b3a60e3bcf,
title = "Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension",
abstract = "Aims: To examine whether the addition of dorzolamide to timolol monotherapy influences oxygen saturation in the human retina. Methods: Non-invasive spectrophotometric retinal oximetry was used to measure oxygen saturation in retinal vessels. Twenty patients with open-angle glaucoma (11) and ocular hypertension (9) were recruited. The patients were randomised into receiving timolol monotherapy or dorzolamide-timolol combination for an 8-month test period, followed by a second test period, before which the patients switched treatments. Oximetry measurements were performed at 2-month intervals during each period. Of the 20 patients, 13 followed the study protocol into the second test period, and 10 managed all study visits. Results: The oxygen saturation in retinal vessels was stable within the test periods. The mean arteriolar saturation was 96 (2){\%} (mean (SD)) during timolol monotherapy and 97 (2){\%} during dorzolamide-timolol combination therapy (p=0.17, all patients pooled, n=13). Corresponding values in venules were 66 (5){\%} during timolol monotherapy and 65 (6){\%} during dorzolamide-timolol therapy (p=0.13). Patients who started on dorzolamide-timolol combination showed a significant reduction in arteriolar (98 (2){\%} to 95 (2){\%}, p<0.01) and venular saturation (69 (5){\%} to 66 (6){\%}, p<0.05) when changing to timolol monotherapy. Conclusion: Adding dorzolamide to timolol monotherapy has a minimal effect, but going from dorzolamide-timolol combination to timolol alone lowered arteriolar and venular oxygen saturation. The retinal oxygen saturation measurements show a high degree of stability over an extended period of time. Previous studies have suggested increased retinal and optic nerve blood flow with dorzolamide. Unchanged oxygen saturation and increased blood flow would indicate increased oxygen delivery to the retina.",
author = "S. Traustason and Hardarson, {S. H.} and Gottfredsdottir, {M. S.} and T. Eysteinsson and Karlsson, {R. A.} and E. Stef{\'a}nsson and Alon Harris",
year = "2009",
month = "8",
doi = "10.1136/bjo.2008.148460",
language = "English",
volume = "93",
pages = "1064--1067",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension

AU - Traustason, S.

AU - Hardarson, S. H.

AU - Gottfredsdottir, M. S.

AU - Eysteinsson, T.

AU - Karlsson, R. A.

AU - Stefánsson, E.

AU - Harris, Alon

PY - 2009/8

Y1 - 2009/8

N2 - Aims: To examine whether the addition of dorzolamide to timolol monotherapy influences oxygen saturation in the human retina. Methods: Non-invasive spectrophotometric retinal oximetry was used to measure oxygen saturation in retinal vessels. Twenty patients with open-angle glaucoma (11) and ocular hypertension (9) were recruited. The patients were randomised into receiving timolol monotherapy or dorzolamide-timolol combination for an 8-month test period, followed by a second test period, before which the patients switched treatments. Oximetry measurements were performed at 2-month intervals during each period. Of the 20 patients, 13 followed the study protocol into the second test period, and 10 managed all study visits. Results: The oxygen saturation in retinal vessels was stable within the test periods. The mean arteriolar saturation was 96 (2)% (mean (SD)) during timolol monotherapy and 97 (2)% during dorzolamide-timolol combination therapy (p=0.17, all patients pooled, n=13). Corresponding values in venules were 66 (5)% during timolol monotherapy and 65 (6)% during dorzolamide-timolol therapy (p=0.13). Patients who started on dorzolamide-timolol combination showed a significant reduction in arteriolar (98 (2)% to 95 (2)%, p<0.01) and venular saturation (69 (5)% to 66 (6)%, p<0.05) when changing to timolol monotherapy. Conclusion: Adding dorzolamide to timolol monotherapy has a minimal effect, but going from dorzolamide-timolol combination to timolol alone lowered arteriolar and venular oxygen saturation. The retinal oxygen saturation measurements show a high degree of stability over an extended period of time. Previous studies have suggested increased retinal and optic nerve blood flow with dorzolamide. Unchanged oxygen saturation and increased blood flow would indicate increased oxygen delivery to the retina.

AB - Aims: To examine whether the addition of dorzolamide to timolol monotherapy influences oxygen saturation in the human retina. Methods: Non-invasive spectrophotometric retinal oximetry was used to measure oxygen saturation in retinal vessels. Twenty patients with open-angle glaucoma (11) and ocular hypertension (9) were recruited. The patients were randomised into receiving timolol monotherapy or dorzolamide-timolol combination for an 8-month test period, followed by a second test period, before which the patients switched treatments. Oximetry measurements were performed at 2-month intervals during each period. Of the 20 patients, 13 followed the study protocol into the second test period, and 10 managed all study visits. Results: The oxygen saturation in retinal vessels was stable within the test periods. The mean arteriolar saturation was 96 (2)% (mean (SD)) during timolol monotherapy and 97 (2)% during dorzolamide-timolol combination therapy (p=0.17, all patients pooled, n=13). Corresponding values in venules were 66 (5)% during timolol monotherapy and 65 (6)% during dorzolamide-timolol therapy (p=0.13). Patients who started on dorzolamide-timolol combination showed a significant reduction in arteriolar (98 (2)% to 95 (2)%, p<0.01) and venular saturation (69 (5)% to 66 (6)%, p<0.05) when changing to timolol monotherapy. Conclusion: Adding dorzolamide to timolol monotherapy has a minimal effect, but going from dorzolamide-timolol combination to timolol alone lowered arteriolar and venular oxygen saturation. The retinal oxygen saturation measurements show a high degree of stability over an extended period of time. Previous studies have suggested increased retinal and optic nerve blood flow with dorzolamide. Unchanged oxygen saturation and increased blood flow would indicate increased oxygen delivery to the retina.

UR - http://www.scopus.com/inward/record.url?scp=68049088540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68049088540&partnerID=8YFLogxK

U2 - 10.1136/bjo.2008.148460

DO - 10.1136/bjo.2008.148460

M3 - Article

C2 - 19416932

AN - SCOPUS:68049088540

VL - 93

SP - 1064

EP - 1067

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 8

ER -