Dose determinants in continuous renal replacement therapy

William R. Clark, Joseph E. Turk, Michael Kraus, Dayong Gao

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Increasing attention is being paid to quantifying the dose of dialysis prescribed and delivered to critically ill patients with acute renal failure (ARF). Recent trials in both the intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) realms have suggested that a direct relationship between dose and survival exists for both of these therapies. The purpose of this review, first, is to analyze critically the above-mentioned dose/outcome studies in acute dialysis. Subsequently, the factors influencing dose prescription and delivery are discussed, with the focus on continuous venovenous hemofiltration (CVVH). Specifically, differences between postdilution and predilution CVVH will be highlighted, and the importance of blood flow rate in dose delivery for these therapies will be discussed.

Original languageEnglish
Pages (from-to)815-820
Number of pages6
JournalArtificial Organs
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint

Hemofiltration
Renal Replacement Therapy
Dialysis
Acute Kidney Injury
Critical Illness
Prescriptions
Renal Dialysis
Blood
Flow rate
Outcome Assessment (Health Care)
Survival
Therapeutics

Keywords

  • Continuous renal replacement therapy
  • Dose
  • Hemodialysis
  • Hemofiltration

ASJC Scopus subject areas

  • Biophysics

Cite this

Dose determinants in continuous renal replacement therapy. / Clark, William R.; Turk, Joseph E.; Kraus, Michael; Gao, Dayong.

In: Artificial Organs, Vol. 27, No. 9, 01.09.2003, p. 815-820.

Research output: Contribution to journalArticle

Clark, William R. ; Turk, Joseph E. ; Kraus, Michael ; Gao, Dayong. / Dose determinants in continuous renal replacement therapy. In: Artificial Organs. 2003 ; Vol. 27, No. 9. pp. 815-820.
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