Dose determinants in continuous renal replacement therapy

William R. Clark, Joseph E. Turk, Michael A. Kraus, Dayong Gao

Research output: Contribution to journalReview article

66 Scopus citations


Increasing attention is being paid to quantifying the dose of dialysis prescribed and delivered to critically ill patients with acute renal failure (ARF). Recent trials in both the intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) realms have suggested that a direct relationship between dose and survival exists for both of these therapies. The purpose of this review, first, is to analyze critically the above-mentioned dose/outcome studies in acute dialysis. Subsequently, the factors influencing dose prescription and delivery are discussed, with the focus on continuous venovenous hemofiltration (CVVH). Specifically, differences between postdilution and predilution CVVH will be highlighted, and the importance of blood flow rate in dose delivery for these therapies will be discussed.

Original languageEnglish (US)
Pages (from-to)815-820
Number of pages6
JournalArtificial Organs
Issue number9
StatePublished - Sep 1 2003


  • Continuous renal replacement therapy
  • Dose
  • Hemodialysis
  • Hemofiltration

ASJC Scopus subject areas

  • Biophysics

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