Double-Blind Comparator Trials with Pinacidil, a Potassium Channel Opener

J. T. Callaghan, M. R. Goldberg, R. Brunelle

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The antihypertensive effects of pinacidil, a potassium channel opener, were studied in 4, dose titration, double-blind trials. Patients had mild to severe hypertension, with supine diastolic arterial pressures between 91 and 150mm Hg during the qualification assessment. Efficacy was assessed using an ‘intention-to-treat’ analysis. In one study, pinacidil-treated patients had a response rate significantly greater than placebo-treated patients. In another study, the pinacidil group had a response rate significantly greater than the prazosin group (83% vs 75%, respectively). In a third study, the response rate in the pinacidil group was marginally greater than in the hydralazine group (77% vs 73%, respectively). In a ‘step 2’ trial, pinacidil was as effective as methyldopa and more effective than placebo. Adverse experiences with pinacidil were associated with vasodilatation. Electrocardiographic T wave changes occurred intermittently and may be related to its mechanism of action. These studies suggest that antihypertensive monotherapy with pinacidil was effective and generally well tolerated.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalDrugs
Volume36
Issue number7
DOIs
StatePublished - Dec 1988

ASJC Scopus subject areas

  • Pharmacology (medical)

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