Double patch closure of ventricular septal defect with increased pulmonary vascular resistance

W. M. Novick, A. T. Gurbuz, D. C. Watson, V. V. Lazorishinets, A. N. Perepeka, I. Malcic, B. Marinovic, B. S. Alpert, T. G. DiSessa, P. J. Del Nido, P. B. Manning, J. W. Brown

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background. Closure of a large ventricular septal defect (VSD) in children with elevated pulmonary vascular resistance is associated with significant morbidity and mortality. Pulmonary hypertensive episodes continue to be a major cause of postoperative morbidity and mortality. We designed a fenestrated flap valve double VSD patch in an effort to decrease the morbidity and mortality associated with the closure of a large VSD with elevated pulmonary vascular resistance. Methods. Eighteen children (mean age, 5.7 years) with a large VSD and elevated pulmonary vascular resistance (mean, 11.4 Wood units) underwent double patch VSD closure using moderately hypothermic cardiopulmonary bypass and cardioplegic arrest. The routine VSD patch was fenestrated (4 to 6 mm) and on the left ventricular side of the patch, a second, smaller patch was attached to the fenestration along its superior margin before closure of the VSD. Results. All children survived operation and were weaned from inotropic and ventilator support within 48 hours postoperatively. Postoperative pulmonary artery pressures were significantly lower than preoperative values. One child died 9 months postoperatively. Conclusions. Closure of a large VSD in children with elevated pulmonary vascular resistance can be performed with low morbidity and mortality when a flap valve double VSD patch is used.

Original languageEnglish (US)
Pages (from-to)1533-1537
Number of pages5
JournalAnnals of Thoracic Surgery
Volume66
Issue number5
DOIs
StatePublished - Jan 1 1998

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Ventricular Heart Septal Defects
Vascular Resistance
Morbidity
Mortality
Mechanical Ventilators
Cardiopulmonary Bypass
Pulmonary Artery
Pressure
Lung

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Novick, W. M., Gurbuz, A. T., Watson, D. C., Lazorishinets, V. V., Perepeka, A. N., Malcic, I., ... Brown, J. W. (1998). Double patch closure of ventricular septal defect with increased pulmonary vascular resistance. Annals of Thoracic Surgery, 66(5), 1533-1537. https://doi.org/10.1016/S0003-4975(98)00956-4

Double patch closure of ventricular septal defect with increased pulmonary vascular resistance. / Novick, W. M.; Gurbuz, A. T.; Watson, D. C.; Lazorishinets, V. V.; Perepeka, A. N.; Malcic, I.; Marinovic, B.; Alpert, B. S.; DiSessa, T. G.; Del Nido, P. J.; Manning, P. B.; Brown, J. W.

In: Annals of Thoracic Surgery, Vol. 66, No. 5, 01.01.1998, p. 1533-1537.

Research output: Contribution to journalArticle

Novick, WM, Gurbuz, AT, Watson, DC, Lazorishinets, VV, Perepeka, AN, Malcic, I, Marinovic, B, Alpert, BS, DiSessa, TG, Del Nido, PJ, Manning, PB & Brown, JW 1998, 'Double patch closure of ventricular septal defect with increased pulmonary vascular resistance', Annals of Thoracic Surgery, vol. 66, no. 5, pp. 1533-1537. https://doi.org/10.1016/S0003-4975(98)00956-4
Novick WM, Gurbuz AT, Watson DC, Lazorishinets VV, Perepeka AN, Malcic I et al. Double patch closure of ventricular septal defect with increased pulmonary vascular resistance. Annals of Thoracic Surgery. 1998 Jan 1;66(5):1533-1537. https://doi.org/10.1016/S0003-4975(98)00956-4
Novick, W. M. ; Gurbuz, A. T. ; Watson, D. C. ; Lazorishinets, V. V. ; Perepeka, A. N. ; Malcic, I. ; Marinovic, B. ; Alpert, B. S. ; DiSessa, T. G. ; Del Nido, P. J. ; Manning, P. B. ; Brown, J. W. / Double patch closure of ventricular septal defect with increased pulmonary vascular resistance. In: Annals of Thoracic Surgery. 1998 ; Vol. 66, No. 5. pp. 1533-1537.
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abstract = "Background. Closure of a large ventricular septal defect (VSD) in children with elevated pulmonary vascular resistance is associated with significant morbidity and mortality. Pulmonary hypertensive episodes continue to be a major cause of postoperative morbidity and mortality. We designed a fenestrated flap valve double VSD patch in an effort to decrease the morbidity and mortality associated with the closure of a large VSD with elevated pulmonary vascular resistance. Methods. Eighteen children (mean age, 5.7 years) with a large VSD and elevated pulmonary vascular resistance (mean, 11.4 Wood units) underwent double patch VSD closure using moderately hypothermic cardiopulmonary bypass and cardioplegic arrest. The routine VSD patch was fenestrated (4 to 6 mm) and on the left ventricular side of the patch, a second, smaller patch was attached to the fenestration along its superior margin before closure of the VSD. Results. All children survived operation and were weaned from inotropic and ventilator support within 48 hours postoperatively. Postoperative pulmonary artery pressures were significantly lower than preoperative values. One child died 9 months postoperatively. Conclusions. Closure of a large VSD in children with elevated pulmonary vascular resistance can be performed with low morbidity and mortality when a flap valve double VSD patch is used.",
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AU - Gurbuz, A. T.

AU - Watson, D. C.

AU - Lazorishinets, V. V.

AU - Perepeka, A. N.

AU - Malcic, I.

AU - Marinovic, B.

AU - Alpert, B. S.

AU - DiSessa, T. G.

AU - Del Nido, P. J.

AU - Manning, P. B.

AU - Brown, J. W.

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