Down-regulation by drugs of the increased signal transduction in cancer cells

George Weber, Fei Shen, Noemi Prajda, Margit Abonyi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. Signal transduction capacity is amplified in cancer cells. 2. Drugs which down-regulate or inhibit the activities of PI 4-kinase and PIP kinase reduce IP3 concentration in cancer cells. 3. Tiazofurin, quercetin, genistein, tamoxifen and ribavirin inhibit in various phases of the cell cycle and at different attacking points of signal transduction. 4. Combinations are synergistic in cytotoxicity and in reducing IP3 concentration: tiazofurin + quercetin, tiazofurin + genistein, tiazofurin + tamoxifen, tamoxifen + genistein, ribavirin + quercetin, and quercetin + genistein.

Original languageEnglish
Pages (from-to)19-34
Number of pages16
JournalAdvances in Enzyme Regulation
Volume40
DOIs
StatePublished - Jun 1 2000

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tiazofurin
Signal transduction
Genistein
Quercetin
Signal Transduction
Tamoxifen
Down-Regulation
Cells
Ribavirin
Pharmaceutical Preparations
Neoplasms
1-Phosphatidylinositol 4-Kinase
Cytotoxicity
Cell Cycle
Phosphotransferases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Down-regulation by drugs of the increased signal transduction in cancer cells. / Weber, George; Shen, Fei; Prajda, Noemi; Abonyi, Margit.

In: Advances in Enzyme Regulation, Vol. 40, 01.06.2000, p. 19-34.

Research output: Contribution to journalArticle

Weber, George ; Shen, Fei ; Prajda, Noemi ; Abonyi, Margit. / Down-regulation by drugs of the increased signal transduction in cancer cells. In: Advances in Enzyme Regulation. 2000 ; Vol. 40. pp. 19-34.
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