Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development

David L. Mack, David S. Leibowitz, Scott Cooper, Heather Ramsey, Hal E. Broxmeyer, Robert Hromas

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Her in T cells (CDIIa/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.

Original languageEnglish (US)
Pages (from-to)444-451
Number of pages8
JournalImmunology
Volume107
Issue number4
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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