Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development

David L. Mack, David S. Leibowitz, Scott Cooper, Heather Ramsey, Hal Broxmeyer, Robert Hromas

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Her in T cells (CDIIa/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalImmunology
Volume107
Issue number4
DOIs
StatePublished - Dec 1 2002

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Homeodomain Proteins
Down-Regulation
T-Lymphocytes
Transgenic Mice
Homeobox Genes
Myeloid Cells
Leukemia
B-Lymphocytes
Up-Regulation

ASJC Scopus subject areas

  • Immunology

Cite this

Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. / Mack, David L.; Leibowitz, David S.; Cooper, Scott; Ramsey, Heather; Broxmeyer, Hal; Hromas, Robert.

In: Immunology, Vol. 107, No. 4, 01.12.2002, p. 444-451.

Research output: Contribution to journalArticle

Mack, David L. ; Leibowitz, David S. ; Cooper, Scott ; Ramsey, Heather ; Broxmeyer, Hal ; Hromas, Robert. / Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. In: Immunology. 2002 ; Vol. 107, No. 4. pp. 444-451.
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