Dr. Harvey Cushing's attempts to cure migraine based on theories of pathophysiology: Historical vignette

Katherine Latimer, Courtney Pendleton, Jason Rosenberg, Aaron A. Cohen-Gadol, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A multitude of theories characterized medical thought on migraine in the early 20th century. Newly discovered historical case files revealed Dr. Harvey Cushing's previously unpublished early attempts at surgical cure of migraine. Following institutional review board approval, and through the courtesy of the Alan Mason Chesney Archives, the authors reviewed the microfilm surgical records for The Johns Hopkins Hospital from 1896 to 1912. Patients undergoing surgical intervention by Dr. Harvey Cushing for the treatment of migraine were selected for further review. All 4 patients in the series were women and ranged in age from 29 to 41 years old. The women were admitted and observed in the hospital until a migraine occurred. Surgeries were performed while the women were in the midst of an attack. Cushing used surgical strategies including decompression, temporal artery ligation, and removal of the spine of the second vertebra. In each case, the patients' headaches eventually returned following surgery. Cushing relied on a combination of contemporary theories on migraine including humeral science, vasospastic theory, organic cause, and increased intracranial pressure. His unpublished efforts foreshadowed future surgical efforts at curing migraines.

Original languageEnglish (US)
Pages (from-to)924-928
Number of pages5
JournalJournal of neurosurgery
Volume115
Issue number5
DOIs
StatePublished - Nov 1 2011

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Migraine Disorders
Spine
Temporal Arteries
Research Ethics Committees
Intracranial Pressure
Decompression
Ligation
Headache

Keywords

  • Harvey Cushing
  • Headache
  • History
  • Migraine
  • Pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Dr. Harvey Cushing's attempts to cure migraine based on theories of pathophysiology : Historical vignette. / Latimer, Katherine; Pendleton, Courtney; Rosenberg, Jason; Cohen-Gadol, Aaron A.; Quiñones-Hinojosa, Alfredo.

In: Journal of neurosurgery, Vol. 115, No. 5, 01.11.2011, p. 924-928.

Research output: Contribution to journalArticle

Latimer, Katherine ; Pendleton, Courtney ; Rosenberg, Jason ; Cohen-Gadol, Aaron A. ; Quiñones-Hinojosa, Alfredo. / Dr. Harvey Cushing's attempts to cure migraine based on theories of pathophysiology : Historical vignette. In: Journal of neurosurgery. 2011 ; Vol. 115, No. 5. pp. 924-928.
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