Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes

Julian C. Rayner, Tuan  Tran, Vladimir Corredor, Curtis S. Huber, John W. Barnwell, Mary R. Galinski

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Malaria parasite proteins involved in erythrocyte invasion are considered important vaccine targets. Members of the reticulocyte binding-like (RBL) family of Plasmodium merozoite proteins are found in human, simian, and rodent malaria parasites and function in the initial steps of erythrocyte selection and invasion. The RBL genes are large, ranging in size from 7.7 to 10 kb, and the extent of any sequence diversity in parasite populations is unknown. We present the first assessment of sequence diversity within RBL genes from the two major human malaria parasites: Plasmodium falciparum and P, vivax. Polymorphism within the RBL genes is generally limited, except for P. vivax reticulocyte binding protein 2 (PvRBP2), which has nucleotide diversity levels 25-fold higher than the other RBL genes. The PvRBP2 haplotypes appear to fall into two distinct classes of alleles, suggesting large-scale dimorphism in this gene. Polymorphisms were frequently clustered, suggesting that different RBL domains may be evolving under different selection and functional pressures.

Original languageEnglish (US)
Pages (from-to)666-674
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume72
Issue number6
StatePublished - Jun 2005
Externally publishedYes

Fingerprint

Plasmodium vivax
Reticulocytes
Plasmodium falciparum
Parasites
Genes
Malaria
Erythrocytes
Merozoites
Plasmodium
Falciparum Malaria
Haplotypes
Rodentia
Proteins
Vaccines
Nucleotides
Alleles
Pressure
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes. / Rayner, Julian C.; Tran, Tuan ; Corredor, Vladimir; Huber, Curtis S.; Barnwell, John W.; Galinski, Mary R.

In: American Journal of Tropical Medicine and Hygiene, Vol. 72, No. 6, 06.2005, p. 666-674.

Research output: Contribution to journalArticle

Rayner, Julian C. ; Tran, Tuan  ; Corredor, Vladimir ; Huber, Curtis S. ; Barnwell, John W. ; Galinski, Mary R. / Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes. In: American Journal of Tropical Medicine and Hygiene. 2005 ; Vol. 72, No. 6. pp. 666-674.
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