Droperidol vs. prochlorperazine for the treatment of acute headache

Christopher Weaver, James B. Jones, Carey D. Chisholm, Michael J. Foley, Beverly K. Giles, Geoffrey G. Somerville, Edward J. Brizendine, William H. Cordell

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

To determine if droperidol i.v. is as effective as prochlorperazine i.v. in the emergency department (ED) treatment of uncomplicated headache, a randomized, controlled, blinded study was conducted in the Emergency Departments of two urban teaching hospitals. Patients ≥ 18 years old with crescendo-onset headache were eligible for inclusion. Ninety-six patients (48 in each group) were randomized to receive droperidol 2.5 mg i.v. or prochlorperazine 10 mg i.v. Baseline characteristics were similar between the two study groups. For the main study outcome, 83.3% in the droperidol group and 72.3% in the prochlorperazine group reported 50% pain reduction at 30 min (p < .01; one-sided test of equivalence). The mean decrease in headache intensity was 79.1% (SD 28.5%) in the droperidol group and 72.1% (SD 28.0%) in the prochlorperazine group (p = .23). It is concluded that droperidol i.v. provided a similar reduction of headache as achieved with prochlorperazine i.v. with a similar incidence of akathisia.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalJournal of Emergency Medicine
Volume26
Issue number2
DOIs
StatePublished - Feb 2004

Fingerprint

Prochlorperazine
Droperidol
Headache
Hospital Emergency Service
Therapeutics
Psychomotor Agitation
Emergency Treatment
Urban Hospitals
Teaching Hospitals
Outcome Assessment (Health Care)
Pain
Incidence

Keywords

  • Droperidol
  • Headache
  • Pain
  • Prochlorperazine

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Weaver, C., Jones, J. B., Chisholm, C. D., Foley, M. J., Giles, B. K., Somerville, G. G., ... Cordell, W. H. (2004). Droperidol vs. prochlorperazine for the treatment of acute headache. Journal of Emergency Medicine, 26(2), 145-150. https://doi.org/10.1016/j.jemermed.2003.05.005

Droperidol vs. prochlorperazine for the treatment of acute headache. / Weaver, Christopher; Jones, James B.; Chisholm, Carey D.; Foley, Michael J.; Giles, Beverly K.; Somerville, Geoffrey G.; Brizendine, Edward J.; Cordell, William H.

In: Journal of Emergency Medicine, Vol. 26, No. 2, 02.2004, p. 145-150.

Research output: Contribution to journalArticle

Weaver, C, Jones, JB, Chisholm, CD, Foley, MJ, Giles, BK, Somerville, GG, Brizendine, EJ & Cordell, WH 2004, 'Droperidol vs. prochlorperazine for the treatment of acute headache', Journal of Emergency Medicine, vol. 26, no. 2, pp. 145-150. https://doi.org/10.1016/j.jemermed.2003.05.005
Weaver, Christopher ; Jones, James B. ; Chisholm, Carey D. ; Foley, Michael J. ; Giles, Beverly K. ; Somerville, Geoffrey G. ; Brizendine, Edward J. ; Cordell, William H. / Droperidol vs. prochlorperazine for the treatment of acute headache. In: Journal of Emergency Medicine. 2004 ; Vol. 26, No. 2. pp. 145-150.
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