Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance

Nancy L. Urizar, Zhiyong Yang, Howard Edenberg, Ronald L. Davis

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The molecular mechanisms occurring in the nervous system that underlie behavioral responses to ethanol remain poorly understood. Here, we report that molecular requirements for two of these responses, initial sensitivity and the development of rapid tolerance, comap to the same small set of neurons. We show that null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and failure to develop normal levels of rapid tolerance. Both the sensitivity and rapid tolerance phenotypes of the homer mutants are rescued by the expression of wild-type homer in a subset of neurons that include the ellipsoid body. Thus, some of the molecular- and systems-level requirements for these two behavioral responses to ethanol are identical.

Original languageEnglish
Pages (from-to)4541-4551
Number of pages11
JournalJournal of Neuroscience
Volume27
Issue number17
DOIs
StatePublished - Apr 25 2007

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Drosophila
Ethanol
Neurons
Hypnotics and Sedatives
Diptera
Nervous System
Phenotype

Keywords

  • Drosophila
  • Ellipsoid body
  • Ethanol
  • Homer
  • Sensitivity
  • Tolerance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. / Urizar, Nancy L.; Yang, Zhiyong; Edenberg, Howard; Davis, Ronald L.

In: Journal of Neuroscience, Vol. 27, No. 17, 25.04.2007, p. 4541-4551.

Research output: Contribution to journalArticle

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