Überlegungen zur arzneimitteldosierung bei patienten mit akuter und chronischer nierenerkrankung - Eine klinische aktualisierung von Kidney Disease: Improving Global Outcomes (KDIGO)

Translated title of the contribution: Drug dosing consideration in patients with acute and chronic kidney disease - A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)

G. R. Matzke, G. R. Aronoff, A. J. Atkinson, W. M. Bennett, B. S. Decker, K. U. Eckardt, T. Golper, D. W. Grabe, B. Kasiske, F. Keller, J. T. Kielstein, R. Mehta, B. A. Mueller, D. A. Pasko, F. Schaefer, D. A. Sica, L. A. Inker, J. G. Umans, P. Murray

Research output: Contribution to journalReview article

Abstract

Drug dosage adjustment for patients with acute or chronic kidney disease is an accepted standard of practice. The challenge is how to accurately estimate a patient's kidney function in both acute and chronic kidney disease and determine the influence of renal replacement therapies on drug disposition. Kidney Disease: Improving Global Outcomes (KDIGO) held a conference to investigate these issues and propose recommendations for practitioners, researchers, and those involved in the drug development and regulatory arenas. The conference attendees discussed themajor challenges facing drug dosage adjustment for patients with kidney disease. In particular, although glomerular filtration rate is the metric used to guide dose adjustment, kidney disease does affect nonrenal clearances, and this is not adequately considered in most pharmacokinetic studies. There are also inadequate studies in patients receiving all forms of renal replacement therapy and in the pediatric population. The conference generated 37 recommendations for clinical practice, 32 recommendations for future research directions, and 24 recommendations for regulatory agencies (US Food and Drug Administration and European Medicines Agency) to enhance the quality of pharmacokinetic and pharmacodynamic information available to clinicians. The KDIGO Conference highlighted the gaps and focused on crafting paths to the future that will stimulate research and improve the global outcomes of patients with acute and chronic kidney disease.

Translated title of the contributionDrug dosing consideration in patients with acute and chronic kidney disease - A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)
Original languageGerman
Pages (from-to)45-61
Number of pages17
JournalNieren- und Hochdruckkrankheiten
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Acute kidney injury (AKI)
  • Chronic kidney disease (CKD)
  • Continuous renal replacement therapy
  • Drug dosing
  • Hemodialysis
  • Pharmacokinetics

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

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    Matzke, G. R., Aronoff, G. R., Atkinson, A. J., Bennett, W. M., Decker, B. S., Eckardt, K. U., Golper, T., Grabe, D. W., Kasiske, B., Keller, F., Kielstein, J. T., Mehta, R., Mueller, B. A., Pasko, D. A., Schaefer, F., Sica, D. A., Inker, L. A., Umans, J. G., & Murray, P. (2012). Überlegungen zur arzneimitteldosierung bei patienten mit akuter und chronischer nierenerkrankung - Eine klinische aktualisierung von Kidney Disease: Improving Global Outcomes (KDIGO). Nieren- und Hochdruckkrankheiten, 41(2), 45-61. https://doi.org/10.5414/NHX01415