Drug-induced hepatic steatosis

David E. Amacher, Naga Chalasani

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Several drugs have been associated with the potential for drug-induced hepatic steatosis (DIHS) and/or phospholipidosis (DIPL), a lysosomal storage disorder. Drug-induced hepatic steatosis is generally a chronic but reversible affliction and may involve drug accumulation in the liver. Fat accumulation may be either macrovesicular or microvesicular in nature. Commonly used medications associated with DIHS include amiodarone, valproate, tamoxifen, methotrexate, and some chemotherapeutic and antiretroviral agents. Two recently approved medications for the treatment of hereditary homozygous hypercholesterolemia have also been noted to cause hepatic steatosis. For some compounds such as methotrexate and tamoxifen, the underlying metabolic risk factors such as obesity and metabolic syndrome may exacerbate their potential to cause DIHS and its progression. In this article, the authors discuss the preclinical screening and mechanisms of DIHS and DIPL, and review specific examples of drugs commonly used in clinical practice that are known to cause DIHS.

Original languageEnglish (US)
Pages (from-to)205-214
Number of pages10
JournalSeminars in Liver Disease
Volume34
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • drug-induced hepatic steatosis
  • drug-induced steatohepatitis

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

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