Drug Insight: VEGF as a therapeutic target for breast cancer

Bryan P. Schneider, George W. Sledge

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Angiogenesis is implicated in the pathogenesis of malignancy and metastasis. Inhibition of angiogenesis has demonstrated clinically significant improvements in outcomes in a variety of malignancies, including breast cancer. The humanized monoclonal antibody against VEGF, bevacizumab, is the clinically most mature of the antiangiogenic agents and has recently been shown to improve outcome when combined with chemotherapy in the first-line metastatic setting of breast cancer. A variety of other antiangiogenic agents are currently under investigation, including drugs that inhibit the VEGF receptor 2, the cognate receptor for VEGF found on endothelial cells. The combination of antiangiogenic drugs with one another and with other biologic agents is also being explored in an attempt to improve efficacy and to overcome the drug resistance seen with the initial studies of antiangiogenic agents. This Review will focus on the current state of therapeutics designed to inhibit this angiogenic process in breast cancer.

Original languageEnglish (US)
Pages (from-to)181-189
Number of pages9
JournalNature Clinical Practice Oncology
Volume4
Issue number3
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Oncology

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