Drug interactions with herbal products and grapefruit juice: A conference report

Shiew Mei Huang, Stephen D. Hall, Paul Watkins, Lori A. Love, Cosette Serabjit-Singh, Joseph M. Betz, Freddie Ann Hoffman, Peter Honig, Paul M. Coates, Jonca Bull, Shaw T. Chen, Gregory L. Kearns, Michael D. Murray

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Drug interactions with herbal products and food are an evolving knowledge base. Recent examples of protease inhibitors and St John's wort provide compelling evidence of the necessity of adequate pharmacovigilance in ascertaining heretofore unanticipated but preventable drug-herbal interactions. Clinical pharmacology studies of potential significant interactions in phase 1 and phase 2 trials, as well as phase 3 trials, will require a heightened awareness of possible herbal product usage by patients and consumers in the intended study population. Ultimately, better mechanisms are needed to encourage communication among patients and physicians about dietary supplements and, in particular herbal drug and food interactions. Patients whose current prescription regimens do not provide complete symptomatic relief are study populations likely to use supplemental herbal products. Such patient populations might include those with cancer, persistent pain, and other refractory long-term diseases. Drug development study protocols, as well as postmarketing risk assessments, are needed to maintain a high level of alertness to potential drug and food interactions and manage patient risk.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalClinical Pharmacology and Therapeutics
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Huang, S. M., Hall, S. D., Watkins, P., Love, L. A., Serabjit-Singh, C., Betz, J. M., Hoffman, F. A., Honig, P., Coates, P. M., Bull, J., Chen, S. T., Kearns, G. L., & Murray, M. D. (2004). Drug interactions with herbal products and grapefruit juice: A conference report. Clinical Pharmacology and Therapeutics, 75(1), 1-12. https://doi.org/10.1016/j.clpt.2003.07.002