Dual but converging roles: A tale of two crests

Michael Olaopa, Simon Conway

Research output: Chapter in Book/Report/Conference proceedingChapter


The aim of this chapter is to explore the formation, specification, and contribution of pre– and post-migratory neural crest cells to organ development during mammalian embryogenesis. Specifically, we have focused on two key subpopulations — the cardiac neural crest and the trunk neural crest. By reviewing the recent stimulating published data about these two key subpopulations, we hope to shed new light on the importance of these two crest cell types and their distinct but similar roles in providing both structural and functional support to derivatives of the cardiovascular and peripheral nervous systems. We will also highlight the varying decisive roles that each neural crest lineage plays during congenital defect pathogenesis, with emphasis on their functional and structural roles in tissue differentiation and stabilisation.

Original languageEnglish (US)
Title of host publicationNeural Crest Stem Cells: Breakthroughs and Applications
PublisherWorld Scientific Publishing Co.
Number of pages39
ISBN (Electronic)9789814343817
ISBN (Print)9814343803, 9789814343800
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

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