Duration of menopausal hot flushes and associated risk factors

Ellen W. Freeman, Mary D. Sammel, Hui Lin, Ziyue Liu, Clarisa R. Gracia

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objective: To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration. Methods:The Penn Ovarian Aging Study cohort was monitored for 13 years. Hot flushes were evaluated at 9-month to 12-month intervals through in-person interviews. The primary outcome was the duration of moderate-to-severe hot flushes estimated by survival analysis (n=259). Potential risk factors included menopausal stage, age, race, reproductive hormone levels, body mass index (BMI), and current smoking. A secondary analysis included women who reported any hot flushes (n=349). Rssults: The median duration of moderate-to-severe hot flushes was 10.2 years and was strongly associated with menopausal stage at onset. Hot flushes that started near entry into the menopause transition had a median duration greater than 11.57 years; onset in the early transition stage had a median duration of 7.35 years (95% confidence interval [CI] 4.94-8.89; P

Original languageEnglish (US)
Pages (from-to)1095-1104
Number of pages10
JournalObstetrics and Gynecology
Volume117
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Survival Analysis
Menopause
Body Mass Index
Cohort Studies
Smoking
Hormones
Confidence Intervals
Interviews

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Duration of menopausal hot flushes and associated risk factors. / Freeman, Ellen W.; Sammel, Mary D.; Lin, Hui; Liu, Ziyue; Gracia, Clarisa R.

In: Obstetrics and Gynecology, Vol. 117, No. 5, 05.2011, p. 1095-1104.

Research output: Contribution to journalArticle

Freeman, Ellen W. ; Sammel, Mary D. ; Lin, Hui ; Liu, Ziyue ; Gracia, Clarisa R. / Duration of menopausal hot flushes and associated risk factors. In: Obstetrics and Gynecology. 2011 ; Vol. 117, No. 5. pp. 1095-1104.
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