Dye dependent differences in arteriovenous passage times: A comparison of indocyanine green and fluorescein sodium dye analysis

Daniel T. Sines, Larry Kagemann, Brent Siesky, Ehud Rechtman, Hanna J. Garzozi, Alon Harris

Research output: Contribution to journalArticle

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■ BACKGROUND AND OBJECTIVE: To evaluate the difference in arteriovenous passage time calculated from retinal angiograms using indocyanine green and fluorescein sodium dye in healthy individuals. ■ PATIENTS AND METHODS: Examinations of eight healthy individuals (mean age ± standard deviation: 27.3 ± 4.2 years) who had four consecutive ophthalmic visits that were 2 weeks apart were analyzed. Indocyanine green and fluorescein angiography were performed sequentially (with the indocyanine green angiography occurring first) using scanning laser ophthalmoscopy. Arteriovenous passage times were calculated offline using digital angiogram video analysis. ■ RESULTS: Mean arteriovenous passage times calculated from indocyanine green angiography (1.417 ± 0.136 seconds) recordings were significantly shorter than fluorescein sodium times (2.539 ± 0.421 seconds) (P < .0001) and intra-group variability was similar. There were no significant correlations between indocyanine green and fluorescein sodium arteriovenous passage times. ■ CONCLUSION: Arteriovenous passage times calculated using indocyanine green and fluorescein angiography are not interchangeable.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging
Issue number3
StatePublished - May 1 2008


ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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