Dynamic SPECT imaging after injection of the benzodiazepine receptor ligand [123I]iomazenil in healthy human subjects

Scott W. Woods, John P. Seibyl, Andrew W. Goddard, Holley M. Dey, Sami S. Zoghbi, Mark Germine, Ronald M. Baldwin, Eileen O. Smith, Dennis S. Charney, George R. Heninger, Paul B. Hoffer, Robert B. Innis

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Previous work suggests that iomazenil (formerly known as Ro 16-0154) is a useful ligand for static imaging of the benzodiazepine (BZ) receptor with single photon emission computed tomography (SPECT). The present study evaluated the feasibility of dynamic SPECT imaging of cerebral radioactivity following intravenous [123I]iomazenil injection in healthy human subjects, in preparation for future receptor quantitation studies. Maximal brain uptake was reached approximately 25-30 minutes after i.v. administration of the radioligand and represented approximately 12% of the injected dose. The regional distribution of radioactive densities was consistent with the known distribution of BZ receptors in human brain, with highest uptake localized over the occipital area. Washout of cortical radioactivity was regionally variable but relatively slow, with a half-life of approximately 4 hours after the time of peak radioactivity. In summary, [123I]iomazenil is a promising SPECT radioligand for the BZ receptor, with high brain uptake, relatively slow washout of radioactivity and appropriate regional distribution.

Original languageEnglish (US)
Pages (from-to)67-77
Number of pages11
JournalPsychiatry Research: Neuroimaging
Volume45
Issue number2
DOIs
StatePublished - Aug 1992

Keywords

  • Ro 16-0154
  • Single photon emission computed tomography
  • brain imaging
  • flumazenil
  • occipital lobes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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    Woods, S. W., Seibyl, J. P., Goddard, A. W., Dey, H. M., Zoghbi, S. S., Germine, M., Baldwin, R. M., Smith, E. O., Charney, D. S., Heninger, G. R., Hoffer, P. B., & Innis, R. B. (1992). Dynamic SPECT imaging after injection of the benzodiazepine receptor ligand [123I]iomazenil in healthy human subjects. Psychiatry Research: Neuroimaging, 45(2), 67-77. https://doi.org/10.1016/0925-4927(92)90001-K