Dynamique de l'excrétion ovulaire de Schistosoma haematobium dans une cohorte de Kalifabougou (Mali) sous traitement par le praziquantel (PZQ) durant cinq ans

Translated title of the contribution: Dynamics of Egg Excretion of Schistosoma haematobium in a Longitudinal Cohort Under Treatment with Praziquantel over a Five-Year Period in Kalifabougou, Mali

D. Safiatou Niaré, D. Doumtabe, A. Ongoiba, K. Sidibé, A. Traoré, J. Sangala, K. Kayentao, Tuan  Tran, P. D. Crompton, B. Traoré, O. K. Doumbo

Research output: Contribution to journalArticle

Abstract

This study aim was to evaluate the dynamics of Schistosoma haematobium eggs excretion after the scaling up of "Mass Drug Administration" (MDA) with praziquantel (PZQ) from 2011 to 2016 in a cohort of volunteers living in the village of Kalifabougou, Mali. We conducted a cross-sectional study on 676 volunteers in May 2011 niched in cohort study from 696 volunteers aged three months to 25 years. The eggs of Schistosoma haematobium (Sh) were tested by urine filtration technique, Soil-transmitted helminth and Schistosoma mansoni by the Kato-Katz technique. Maximal MDA/ PZQ population coverage was 83% in 2015 and no MDA/PZQ n 2014. A total of 676 volunteers was included in this prospective cohort. The prevalence rate of Sh showed a significate decreasing from 2011, 2013 to 2014 with respectively 10.2% [95% CI=10.04-10,18], 5.32% [95% CI=5.30-5.33], and 5.25% [95% CI=524.-5.31], followed by an increase to 10.6% [95% CI = 10.47-10.63] in 2015 and a significative decrease in 2016 to 5.4% [95% CI=3.5-7,3]. Children aged from six to 10 years and mostly boys were more infected with Sh, then could serve of parasite reservoir. MDA with PZQ remains an effective strategy for schistosomiasis control against Sh in Kalifabougou. Additional studies on MDA/PZQ average treatment covering human-water contact behaviors and population migration are necessary to understand the persistence of the 5% annual prevalence rate of egg shedding in the cohort of volunteers periodically treated with PQZ. Testing eggs shed viability will be also an added value.

Original languageFrench
Pages (from-to)114-120
Number of pages7
JournalBulletin de la Societe de pathologie exotique (1990)
Volume111
Issue number2
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Schistosoma haematobium
Mali
Praziquantel
Ovum
Volunteers
Eggs
Pharmaceutical Preparations
Therapeutics
Schistosoma mansoni
Helminths
Schistosomiasis
Population
Parasites
Cohort Studies
Soil
Cross-Sectional Studies
Urine
Water

Keywords

  • Cohort
  • Kalifabougou
  • Mali
  • Mass Drug Administration
  • Praziquantel
  • Prevalence
  • Schistosoma haematobium
  • Sub-Saharan Africa

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Dynamique de l'excrétion ovulaire de Schistosoma haematobium dans une cohorte de Kalifabougou (Mali) sous traitement par le praziquantel (PZQ) durant cinq ans. / Niaré, D. Safiatou; Doumtabe, D.; Ongoiba, A.; Sidibé, K.; Traoré, A.; Sangala, J.; Kayentao, K.; Tran, Tuan ; Crompton, P. D.; Traoré, B.; Doumbo, O. K.

In: Bulletin de la Societe de pathologie exotique (1990), Vol. 111, No. 2, 01.01.2018, p. 114-120.

Research output: Contribution to journalArticle

Niaré, D. Safiatou ; Doumtabe, D. ; Ongoiba, A. ; Sidibé, K. ; Traoré, A. ; Sangala, J. ; Kayentao, K. ; Tran, Tuan  ; Crompton, P. D. ; Traoré, B. ; Doumbo, O. K. / Dynamique de l'excrétion ovulaire de Schistosoma haematobium dans une cohorte de Kalifabougou (Mali) sous traitement par le praziquantel (PZQ) durant cinq ans. In: Bulletin de la Societe de pathologie exotique (1990). 2018 ; Vol. 111, No. 2. pp. 114-120.
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abstract = "This study aim was to evaluate the dynamics of Schistosoma haematobium eggs excretion after the scaling up of {"}Mass Drug Administration{"} (MDA) with praziquantel (PZQ) from 2011 to 2016 in a cohort of volunteers living in the village of Kalifabougou, Mali. We conducted a cross-sectional study on 676 volunteers in May 2011 niched in cohort study from 696 volunteers aged three months to 25 years. The eggs of Schistosoma haematobium (Sh) were tested by urine filtration technique, Soil-transmitted helminth and Schistosoma mansoni by the Kato-Katz technique. Maximal MDA/ PZQ population coverage was 83{\%} in 2015 and no MDA/PZQ n 2014. A total of 676 volunteers was included in this prospective cohort. The prevalence rate of Sh showed a significate decreasing from 2011, 2013 to 2014 with respectively 10.2{\%} [95{\%} CI=10.04-10,18], 5.32{\%} [95{\%} CI=5.30-5.33], and 5.25{\%} [95{\%} CI=524.-5.31], followed by an increase to 10.6{\%} [95{\%} CI = 10.47-10.63] in 2015 and a significative decrease in 2016 to 5.4{\%} [95{\%} CI=3.5-7,3]. Children aged from six to 10 years and mostly boys were more infected with Sh, then could serve of parasite reservoir. MDA with PZQ remains an effective strategy for schistosomiasis control against Sh in Kalifabougou. Additional studies on MDA/PZQ average treatment covering human-water contact behaviors and population migration are necessary to understand the persistence of the 5{\%} annual prevalence rate of egg shedding in the cohort of volunteers periodically treated with PQZ. Testing eggs shed viability will be also an added value.",
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