Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles

Miguel Valderrábano, Moon Hyoung Lee, Toshihiko Ohara, Angela C. Lai, Michael C. Fishbein, Shien-Fong Lin, Hrayr S. Karagueuzian, Peng-Sheng Chen

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The intramural dynamics of ventricular fibrillation (VF) remain poorly understood. Recent investigations have suggested that stable intramural reentry may underlie the mechanisms of VF. We performed optical mapping studies of VF in isolated swine fight ventricles (RVs) and left ventricles (LVs). Nine RV walls were cut obliquely in their distal edge exposing the transmural surface. Six LV wedge preparations were also studied. Results showed that intramural reentry was present. In RV, 28 of 44 VF episodes showed reentry; 15% of the activation pathways were reentrant. Except for 4 episodes, reentry was transmural, involving subendocardial structures as the papillary muscle (PM) or trabeculae. In LV, reentry was observed in 27 of 27 VF episodes; 23% of the activations were part of reentrant pathways (P

Original languageEnglish (US)
Pages (from-to)839-848
Number of pages10
JournalCirculation Research
Volume88
Issue number8
StatePublished - Apr 27 2001
Externally publishedYes

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Ventricular Fibrillation
Swine
Heart Ventricles
Papillary Muscles

Keywords

  • Anisotropy
  • Fibrillation
  • Intramural reentry
  • Papillary muscle
  • Purkinje

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. / Valderrábano, Miguel; Lee, Moon Hyoung; Ohara, Toshihiko; Lai, Angela C.; Fishbein, Michael C.; Lin, Shien-Fong; Karagueuzian, Hrayr S.; Chen, Peng-Sheng.

In: Circulation Research, Vol. 88, No. 8, 27.04.2001, p. 839-848.

Research output: Contribution to journalArticle

Valderrábano, M, Lee, MH, Ohara, T, Lai, AC, Fishbein, MC, Lin, S-F, Karagueuzian, HS & Chen, P-S 2001, 'Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles', Circulation Research, vol. 88, no. 8, pp. 839-848.
Valderrábano M, Lee MH, Ohara T, Lai AC, Fishbein MC, Lin S-F et al. Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circulation Research. 2001 Apr 27;88(8):839-848.
Valderrábano, Miguel ; Lee, Moon Hyoung ; Ohara, Toshihiko ; Lai, Angela C. ; Fishbein, Michael C. ; Lin, Shien-Fong ; Karagueuzian, Hrayr S. ; Chen, Peng-Sheng. / Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. In: Circulation Research. 2001 ; Vol. 88, No. 8. pp. 839-848.
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