Dynamics of the transition from osteoblast to osteocyte

Sarah L. Dallas, Lynda Bonewald

Research output: Chapter in Book/Report/Conference proceedingConference contribution

153 Citations (Scopus)

Abstract

Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone. However, the mechanisms that control the differentiation of osteoblasts into osteocytes embedded in bone matrix are not well understood. With the recent developments of transgenic models for manipulating gene expression in osteocytes and of transgenic mice carrying lineage reporters for osteoblasts and osteocytes, unprecedented new insights are becoming possible. In this article we review recent advances, such as comparative gene and protein expression studies, that are delineating the changes in gene and protein expression that accompany osteocyte differentiation. We also review recent studies in which time-lapse dynamic imaging approaches have been used to visualize osteoblast and osteocyte populations within bone. These approaches reveal the key role of cell motility in bone cell function and highlight the dynamic nature of mineralized tissues. Changes in motile properties of the cell may be key in the transition from osteoblast to osteocyte, as reflected in the altered expression of many molecules involved in cytoskeletal function.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine
Pages437-443
Number of pages7
Volume1192
DOIs
StatePublished - Mar 2010
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1192
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Osteocytes
Osteoblasts
Bone
Gene Expression
Bone and Bones
Time-Lapse Imaging
Gene expression
Bone Matrix
Proteins
Tissue
Transgenic Mice
Imaging techniques
Cell Movement
Molecules
Population

Keywords

  • Bone
  • Cell motility
  • Differentiation
  • Osteoblast
  • Osteocyte

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dallas, S. L., & Bonewald, L. (2010). Dynamics of the transition from osteoblast to osteocyte. In Skeletal Biology and Medicine (Vol. 1192, pp. 437-443). (Annals of the New York Academy of Sciences; Vol. 1192). https://doi.org/10.1111/j.1749-6632.2009.05246.x

Dynamics of the transition from osteoblast to osteocyte. / Dallas, Sarah L.; Bonewald, Lynda.

Skeletal Biology and Medicine. Vol. 1192 2010. p. 437-443 (Annals of the New York Academy of Sciences; Vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dallas, SL & Bonewald, L 2010, Dynamics of the transition from osteoblast to osteocyte. in Skeletal Biology and Medicine. vol. 1192, Annals of the New York Academy of Sciences, vol. 1192, pp. 437-443. https://doi.org/10.1111/j.1749-6632.2009.05246.x
Dallas SL, Bonewald L. Dynamics of the transition from osteoblast to osteocyte. In Skeletal Biology and Medicine. Vol. 1192. 2010. p. 437-443. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.05246.x
Dallas, Sarah L. ; Bonewald, Lynda. / Dynamics of the transition from osteoblast to osteocyte. Skeletal Biology and Medicine. Vol. 1192 2010. pp. 437-443 (Annals of the New York Academy of Sciences).
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