Dyskinesias in Parkinsonian Syndromes

S. Elizabeth Zauber, Christopher G. Goetz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dyskinesia is an involuntary hyperkinetic movement disorder that may occur as a feature of parkinsonism or as an effect of drug treatment for the disease. In Parkinson's disease (PD) dyskinesia is common and may be disabling. The phenomenology of dyskinesia in PD varies primarily due to the level of brain dopamine from dopaminergic drugs in the context of dopaminergic cell degeneration. While changes in the dopaminergic system are essential for the development of dyskinesia, multiple other brain receptor systems are implicated in the pathophysiology. Currently only one drug, amantadine, reduces dyskinesia severity without worsening parkinsonism. Other treatment options consist of changes in dose and timing of dopaminergic drugs, as well as deep brain stimulation surgery.

Original languageEnglish (US)
Title of host publicationHyperkinetic Movement Disorders
Subtitle of host publicationDifferential Diagnosis and Treatment
PublisherWiley-Blackwell
Pages297-310
Number of pages14
ISBN (Print)1444333526, 9781444333527
DOIs
StatePublished - Feb 24 2012

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Keywords

  • Corticobasal degeneration
  • Deep brain stimulation
  • Diphasic dyskinesia
  • Levodopa-induced-dyskinesia
  • Multiple system atrophy
  • Parkinson's disease
  • Pathophysiology
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zauber, S. E., & Goetz, C. G. (2012). Dyskinesias in Parkinsonian Syndromes. In Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment (pp. 297-310). Wiley-Blackwell. https://doi.org/10.1002/9781444346183.ch19