Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors

Sally Sultan, Michael Dowling, Adam Kirton, Gabrielle DeVeber, Alexandra Linds, Mitchell S.V. Elkind, Tim Bernard, Michael Dowling, Marta Hernandez, Michael Rivkin, Ilona Kopyta, Rebecca Ichord, Susan Benedict, Mark Mackay, Adam Kirton, Dimitrios Zafeiriou, Monica Troncoso, Jerome Yager, Lisa Abraham, Warren LoVeronica Gonzalez, Montri Saengpattrachai, Anthony Chan, Abdallah Abdallah, Vesna Brankovic-Sreckovic, Anneli Kolk, Jessica Carpenter, Gordana Kovacevic, Catherine Amlie-Lefond, Maja Steinlin, Juliann Paolicchi, Monroe Carell, Bruce Bjornson, Barry Kosofsky, Virginia Wong, Paola Pergami, Neil Friedman, Yang Guang, Peter Humphreys, Ulrike Nowak-Göttl, Donna Ferriero, Frederico Xavier, Robert Fryer, Lucila Andrade Alveal, Diana Altuna, Ryan Felling, Steven Pavlakis, Eric Grabowski, Meredith Golomb, Michael Noetzel, Chaouki Khoury, Norma Lerner, Amanda Blair, Mubeen Rafay

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. Methods We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non–high-density lipoprotein cholesterol, and hypertriglyceridemia. Results Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol (10.6% versus 7.4%), high non–high-density lipoprotein cholesterol (23.1% versus 8.4%), and low high-density lipoprotein cholesterol (39.8% versus 13.4%). The lipid values that corresponded to one standard deviation above the mean (84th percentile) in multiple published national studies generally corresponded to a lower ranking percentile in children aged five years or older with arterial ischemic stroke. Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. Ethnic background and an acute systemic illness were also associated with abnormal lipids. Conclusions Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalPediatric Neurology
Volume78
DOIs
StatePublished - Jan 1 2018

Fingerprint

Dyslipidemias
Stroke
Lipids
HDL Cholesterol
Hypertriglyceridemia
Body Mass Index
Cholesterol
Pediatrics
Thinness
Nutrition Surveys
Puberty
LDL Cholesterol
Triglycerides
Cross-Sectional Studies
Weights and Measures
Incidence

Keywords

  • body mass index
  • lipids
  • pediatric stroke
  • prevalence
  • risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Sultan, S., Dowling, M., Kirton, A., DeVeber, G., Linds, A., Elkind, M. S. V., ... Rafay, M. (2018). Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors. Pediatric Neurology, 78, 46-54. https://doi.org/10.1016/j.pediatrneurol.2017.09.019

Dyslipidemia in Children With Arterial Ischemic Stroke : Prevalence and Risk Factors. / Sultan, Sally; Dowling, Michael; Kirton, Adam; DeVeber, Gabrielle; Linds, Alexandra; Elkind, Mitchell S.V.; Bernard, Tim; Dowling, Michael; Hernandez, Marta; Rivkin, Michael; Kopyta, Ilona; Ichord, Rebecca; Benedict, Susan; Mackay, Mark; Kirton, Adam; Zafeiriou, Dimitrios; Troncoso, Monica; Yager, Jerome; Abraham, Lisa; Lo, Warren; Gonzalez, Veronica; Saengpattrachai, Montri; Chan, Anthony; Abdallah, Abdallah; Brankovic-Sreckovic, Vesna; Kolk, Anneli; Carpenter, Jessica; Kovacevic, Gordana; Amlie-Lefond, Catherine; Steinlin, Maja; Paolicchi, Juliann; Carell, Monroe; Bjornson, Bruce; Kosofsky, Barry; Wong, Virginia; Pergami, Paola; Friedman, Neil; Guang, Yang; Humphreys, Peter; Nowak-Göttl, Ulrike; Ferriero, Donna; Xavier, Frederico; Fryer, Robert; Andrade Alveal, Lucila; Altuna, Diana; Felling, Ryan; Pavlakis, Steven; Grabowski, Eric; Golomb, Meredith; Noetzel, Michael; Khoury, Chaouki; Lerner, Norma; Blair, Amanda; Rafay, Mubeen.

In: Pediatric Neurology, Vol. 78, 01.01.2018, p. 46-54.

Research output: Contribution to journalArticle

Sultan, S, Dowling, M, Kirton, A, DeVeber, G, Linds, A, Elkind, MSV, Bernard, T, Dowling, M, Hernandez, M, Rivkin, M, Kopyta, I, Ichord, R, Benedict, S, Mackay, M, Kirton, A, Zafeiriou, D, Troncoso, M, Yager, J, Abraham, L, Lo, W, Gonzalez, V, Saengpattrachai, M, Chan, A, Abdallah, A, Brankovic-Sreckovic, V, Kolk, A, Carpenter, J, Kovacevic, G, Amlie-Lefond, C, Steinlin, M, Paolicchi, J, Carell, M, Bjornson, B, Kosofsky, B, Wong, V, Pergami, P, Friedman, N, Guang, Y, Humphreys, P, Nowak-Göttl, U, Ferriero, D, Xavier, F, Fryer, R, Andrade Alveal, L, Altuna, D, Felling, R, Pavlakis, S, Grabowski, E, Golomb, M, Noetzel, M, Khoury, C, Lerner, N, Blair, A & Rafay, M 2018, 'Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors', Pediatric Neurology, vol. 78, pp. 46-54. https://doi.org/10.1016/j.pediatrneurol.2017.09.019
Sultan, Sally ; Dowling, Michael ; Kirton, Adam ; DeVeber, Gabrielle ; Linds, Alexandra ; Elkind, Mitchell S.V. ; Bernard, Tim ; Dowling, Michael ; Hernandez, Marta ; Rivkin, Michael ; Kopyta, Ilona ; Ichord, Rebecca ; Benedict, Susan ; Mackay, Mark ; Kirton, Adam ; Zafeiriou, Dimitrios ; Troncoso, Monica ; Yager, Jerome ; Abraham, Lisa ; Lo, Warren ; Gonzalez, Veronica ; Saengpattrachai, Montri ; Chan, Anthony ; Abdallah, Abdallah ; Brankovic-Sreckovic, Vesna ; Kolk, Anneli ; Carpenter, Jessica ; Kovacevic, Gordana ; Amlie-Lefond, Catherine ; Steinlin, Maja ; Paolicchi, Juliann ; Carell, Monroe ; Bjornson, Bruce ; Kosofsky, Barry ; Wong, Virginia ; Pergami, Paola ; Friedman, Neil ; Guang, Yang ; Humphreys, Peter ; Nowak-Göttl, Ulrike ; Ferriero, Donna ; Xavier, Frederico ; Fryer, Robert ; Andrade Alveal, Lucila ; Altuna, Diana ; Felling, Ryan ; Pavlakis, Steven ; Grabowski, Eric ; Golomb, Meredith ; Noetzel, Michael ; Khoury, Chaouki ; Lerner, Norma ; Blair, Amanda ; Rafay, Mubeen. / Dyslipidemia in Children With Arterial Ischemic Stroke : Prevalence and Risk Factors. In: Pediatric Neurology. 2018 ; Vol. 78. pp. 46-54.
@article{d6379393d53849b9887f87bd2ba3a6da,
title = "Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors",
abstract = "Background Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. Methods We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non–high-density lipoprotein cholesterol, and hypertriglyceridemia. Results Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4{\%} versus 21{\%}), high total cholesterol (10.6{\%} versus 7.4{\%}), high non–high-density lipoprotein cholesterol (23.1{\%} versus 8.4{\%}), and low high-density lipoprotein cholesterol (39.8{\%} versus 13.4{\%}). The lipid values that corresponded to one standard deviation above the mean (84th percentile) in multiple published national studies generally corresponded to a lower ranking percentile in children aged five years or older with arterial ischemic stroke. Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. Ethnic background and an acute systemic illness were also associated with abnormal lipids. Conclusions Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.",
keywords = "body mass index, lipids, pediatric stroke, prevalence, risk factors",
author = "Sally Sultan and Michael Dowling and Adam Kirton and Gabrielle DeVeber and Alexandra Linds and Elkind, {Mitchell S.V.} and Tim Bernard and Michael Dowling and Marta Hernandez and Michael Rivkin and Ilona Kopyta and Rebecca Ichord and Susan Benedict and Mark Mackay and Adam Kirton and Dimitrios Zafeiriou and Monica Troncoso and Jerome Yager and Lisa Abraham and Warren Lo and Veronica Gonzalez and Montri Saengpattrachai and Anthony Chan and Abdallah Abdallah and Vesna Brankovic-Sreckovic and Anneli Kolk and Jessica Carpenter and Gordana Kovacevic and Catherine Amlie-Lefond and Maja Steinlin and Juliann Paolicchi and Monroe Carell and Bruce Bjornson and Barry Kosofsky and Virginia Wong and Paola Pergami and Neil Friedman and Yang Guang and Peter Humphreys and Ulrike Nowak-G{\"o}ttl and Donna Ferriero and Frederico Xavier and Robert Fryer and {Andrade Alveal}, Lucila and Diana Altuna and Ryan Felling and Steven Pavlakis and Eric Grabowski and Meredith Golomb and Michael Noetzel and Chaouki Khoury and Norma Lerner and Amanda Blair and Mubeen Rafay",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.pediatrneurol.2017.09.019",
language = "English (US)",
volume = "78",
pages = "46--54",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Dyslipidemia in Children With Arterial Ischemic Stroke

T2 - Prevalence and Risk Factors

AU - Sultan, Sally

AU - Dowling, Michael

AU - Kirton, Adam

AU - DeVeber, Gabrielle

AU - Linds, Alexandra

AU - Elkind, Mitchell S.V.

AU - Bernard, Tim

AU - Dowling, Michael

AU - Hernandez, Marta

AU - Rivkin, Michael

AU - Kopyta, Ilona

AU - Ichord, Rebecca

AU - Benedict, Susan

AU - Mackay, Mark

AU - Kirton, Adam

AU - Zafeiriou, Dimitrios

AU - Troncoso, Monica

AU - Yager, Jerome

AU - Abraham, Lisa

AU - Lo, Warren

AU - Gonzalez, Veronica

AU - Saengpattrachai, Montri

AU - Chan, Anthony

AU - Abdallah, Abdallah

AU - Brankovic-Sreckovic, Vesna

AU - Kolk, Anneli

AU - Carpenter, Jessica

AU - Kovacevic, Gordana

AU - Amlie-Lefond, Catherine

AU - Steinlin, Maja

AU - Paolicchi, Juliann

AU - Carell, Monroe

AU - Bjornson, Bruce

AU - Kosofsky, Barry

AU - Wong, Virginia

AU - Pergami, Paola

AU - Friedman, Neil

AU - Guang, Yang

AU - Humphreys, Peter

AU - Nowak-Göttl, Ulrike

AU - Ferriero, Donna

AU - Xavier, Frederico

AU - Fryer, Robert

AU - Andrade Alveal, Lucila

AU - Altuna, Diana

AU - Felling, Ryan

AU - Pavlakis, Steven

AU - Grabowski, Eric

AU - Golomb, Meredith

AU - Noetzel, Michael

AU - Khoury, Chaouki

AU - Lerner, Norma

AU - Blair, Amanda

AU - Rafay, Mubeen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. Methods We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non–high-density lipoprotein cholesterol, and hypertriglyceridemia. Results Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol (10.6% versus 7.4%), high non–high-density lipoprotein cholesterol (23.1% versus 8.4%), and low high-density lipoprotein cholesterol (39.8% versus 13.4%). The lipid values that corresponded to one standard deviation above the mean (84th percentile) in multiple published national studies generally corresponded to a lower ranking percentile in children aged five years or older with arterial ischemic stroke. Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. Ethnic background and an acute systemic illness were also associated with abnormal lipids. Conclusions Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.

AB - Background Risk factors for pediatric stroke are poorly understood and require study to improve prevention. Total cholesterol and triglyceride values peak to near-adult levels before puberty, a period of increased stroke incidence. The role of lipids in childhood arterial ischemic stroke has been minimally investigated. Methods We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non–high-density lipoprotein cholesterol, and hypertriglyceridemia. Results Compared with the National Health and Nutrition Examination Survey, a higher proportion of children ≥5 years with arterial ischemic stroke had dyslipidemia (38.4% versus 21%), high total cholesterol (10.6% versus 7.4%), high non–high-density lipoprotein cholesterol (23.1% versus 8.4%), and low high-density lipoprotein cholesterol (39.8% versus 13.4%). The lipid values that corresponded to one standard deviation above the mean (84th percentile) in multiple published national studies generally corresponded to a lower ranking percentile in children aged five years or older with arterial ischemic stroke. Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. Ethnic background and an acute systemic illness were also associated with abnormal lipids. Conclusions Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.

KW - body mass index

KW - lipids

KW - pediatric stroke

KW - prevalence

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85039804129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039804129&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2017.09.019

DO - 10.1016/j.pediatrneurol.2017.09.019

M3 - Article

C2 - 29229232

AN - SCOPUS:85039804129

VL - 78

SP - 46

EP - 54

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

ER -