Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation

Karen L. Wood, Homer L. Twigg, Andrea I. Doseff

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Expansion of CD8+ lymphocyte subsets are found in many states with chronic antigenic exposure including HIV, multiple myeloma, rheumatoid arthritis, CMV infection, transplantation and even normal aging. These expansions are characterized by the expression of CD57 antigen and the loss of CD28-. These lymphocytes are thought to represent clonally expanded cytotoxic T lymphocytes (CTL) that have become senescent and lack proliferative ability. These cells also demonstrate suppressive properties and have been linked with immunodeficiency raising the question of the function of these cells in relationship to immunoregulation. Alterations in the CD95/Fas apoptotic pathway and changes in prosurvival factors such as Hsp27 likely contribute to this lymphocyte subset expansion. Further understanding of the normal CD8 + lymphocyte response to antigen and the factors that lead to abnormal continued expansion in certain disease states will be crucial to understanding the pathogenesis of chronic antigenic stimulation.

Original languageEnglish (US)
Pages (from-to)3771-3781
Number of pages11
JournalFrontiers in Bioscience
Volume14
Issue number10
DOIs
StatePublished - Jan 1 2009

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Keywords

  • Apoptosis
  • Bone marrow transplant
  • Caspases
  • CD57
  • HNK-1
  • Hsp27
  • Lymphocyte
  • Memory cell
  • Review
  • Senescence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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