Early adaptations in collateral and microvascular resistances after ligation of the rat femoral artery

J. L. Unthank, J. C. Nixon, J. M. Lash

Research output: Contribution to journalArticle

36 Scopus citations


Collateral and microvascular (including feed artery) resistances in the rat hindlimb were determined immediately or 1 wk after ligation of the femoral artery. Collateral-to-microvascular resistance ratios were determined from in vivo pressure measurements proximal and distal to the ligation. Microvascular resistance was 32 ± 2.5 and 41 ± 1.5% of the total collateral-dependent vasculature in acutely and chronically ligated limbs, respectively, and decreased 20% in both groups during reactive hyperemia. Minimum resistances of collateral vessels and the microcirculation arising from arterial branches proximal and distal to the ligation were determined by using a modification of the standard hindquarter perfusion technique for determining maximum vascular conductance. One week postligation, minimum total hindquarter resistance was decreased by a reduction in the resistance of the collaterals (~50%) and microcirculation (~33%) proximal to the ligation. The results suggest that the microvasculature distal to the occlusion is able to increase flow by dilation both initially and at 1 wk postligation but that collateral adaptations are primarily responsible for decreases in the minimum total resistance of the collateral-dependent region.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalJournal of Applied Physiology
Issue number1
StatePublished - Jan 1 1995


  • arterial insufficiency
  • collateral arteries
  • femoral artery occlusion
  • microcirculation
  • vascular resistance

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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