Early afterdepolarizations and cardiac arrhythmias

James N. Weiss, Alan Garfinkel, Hrayr S. Karagueuzian, Peng-Sheng Chen, Zhilin Qu

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Early afterdepolarizations (EADs) are an important cause of lethal ventricular arrhythmias in long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular scale cause arrhythmias such as polymorphic ventricular tachycardia (PVT) and torsades de pointes (TdP) at the tissue scale are not well understood. Here we summarize recent progress in this area, discussing (1) the ionic basis of EADs, (2) evidence that deterministic chaos underlies the irregular behavior of EADs, (3) mechanisms by which chaotic EADs synchronize in large numbers of coupled cells in tissue to overcome sourcesink mismatches, (4) how this synchronization process allows EADs to initiate triggers and generate mixed focal reentrant ventricular arrhythmias underlying PVT and TdP, and (5) therapeutic implications.

Original languageEnglish
Pages (from-to)1891-1899
Number of pages9
JournalHeart Rhythm
Volume7
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Cardiac Arrhythmias
Torsades de Pointes
Ventricular Tachycardia
Long QT Syndrome
Heart Failure
Cell Count
Therapeutics

Keywords

  • Afterdepolarization
  • Arrhythmia
  • Chaos synchronization
  • Computer modeling
  • Nonlinear dynamics
  • Sudden cardiac death
  • Systems biology
  • Torsades de pointes
  • Triggered activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Weiss, J. N., Garfinkel, A., Karagueuzian, H. S., Chen, P-S., & Qu, Z. (2010). Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm, 7(12), 1891-1899. https://doi.org/10.1016/j.hrthm.2010.09.017

Early afterdepolarizations and cardiac arrhythmias. / Weiss, James N.; Garfinkel, Alan; Karagueuzian, Hrayr S.; Chen, Peng-Sheng; Qu, Zhilin.

In: Heart Rhythm, Vol. 7, No. 12, 12.2010, p. 1891-1899.

Research output: Contribution to journalArticle

Weiss, JN, Garfinkel, A, Karagueuzian, HS, Chen, P-S & Qu, Z 2010, 'Early afterdepolarizations and cardiac arrhythmias', Heart Rhythm, vol. 7, no. 12, pp. 1891-1899. https://doi.org/10.1016/j.hrthm.2010.09.017
Weiss, James N. ; Garfinkel, Alan ; Karagueuzian, Hrayr S. ; Chen, Peng-Sheng ; Qu, Zhilin. / Early afterdepolarizations and cardiac arrhythmias. In: Heart Rhythm. 2010 ; Vol. 7, No. 12. pp. 1891-1899.
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