Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network

John M. Ringman, Li Jung Liang, Yan Zhou, Sitaram Vangala, Edmond Teng, Sarah Kremen, David Wharton, Alison Goate, Daniel S. Marcus, Martin Farlow, Bernardino Ghetti, Eric McDade, Colin L. Masters, Richard P. Mayeux, Martin Rossor, Stephen Salloway, Peter R. Schofield, Jeffrey L. Cummings, Virginia Buckles, Randall BatemanJohn C. Morris

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Prior studies indicate psychiatric symptoms such as depression, apathy and anxiety are risk factors for or prodromal symptoms of incipient Alzheimer's disease. The study of persons at 50% risk for inheriting autosomal dominant Alzheimer's disease mutations allows characterization of these symptoms before progressive decline in a population destined to develop illness. We sought to characterize early behavioural features in carriers of autosomal dominant Alzheimer's disease mutations. Two hundred and sixty-one persons unaware of their mutation status enrolled in the Dominantly Inherited Alzheimer Network, a study of persons with or at-risk for autosomal dominant Alzheimer's disease, were evaluated with the Neuropsychiatric Inventory-Questionnaire, the 15-item Geriatric Depression Scale and the Clinical Dementia Rating Scale (CDR). Ninety-seven asymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 overtly affected (CDR > 0.5) autosomal dominant Alzheimer's disease mutation carriers were compared to 106 non-carriers with regard to frequency of behavioural symptoms on the Neuropsychiatric Inventory-Questionnaire and severity of depressive symptoms on the Geriatric Depression Scale using generalized linear regression models with appropriate distributions and link functions. Results from the adjusted analyses indicated that depressive symptoms on the Neuropsychiatric Inventory-Questionnaire were less common in cognitively asymptomatic mutation carriers than in non-carriers (5% versus 17%, P = 0.014) and the odds of experiencing at least one behavioural sign in cognitively asymptomatic mutation carriers was lower than in non-carriers (odds ratio = 0.50, 95% confidence interval: 0.26-0.98, P = 0.042). Depression (56% versus 17%, P = 0.0003), apathy (40% versus 4%, P <0.0001), disinhibition (16% versus 2%, P = 0.009), irritability (48% versus 9%, P = 0.0001), sleep changes (28% versus 7%, P = 0.003), and agitation (24% versus 6%, P = 0.008) were more common and the degree of self-rated depression more severe (mean Geriatric Depression Scale score of 2.8 versus 1.4, P = 0.006) in mildly symptomatic mutation carriers relative to non-carriers. Anxiety, appetite changes, delusions, and repetitive motor activity were additionally more common in overtly impaired mutation carriers. Similar to studies of late-onset Alzheimer's disease, we demonstrated increased rates of depression, apathy, and other behavioural symptoms in the mildly symptomatic, prodromal phase of autosomal dominant Alzheimer's disease that increased with disease severity. We did not identify any increased psychopathology in mutation carriers over non-carriers during the presymptomatic stage, suggesting these symptoms result when a threshold of neurodegeneration is reached rather than as life-long qualities. Unexpectedly, we found lower rates of depressive symptoms in cognitively asymptomatic mutation carriers.

Original languageEnglish (US)
Pages (from-to)1036-1045
Number of pages10
JournalBrain
Volume138
Issue number4
DOIs
StatePublished - Apr 1 2015

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Alzheimer Disease
Depression
Mutation
Apathy
Geriatrics
Dementia
Behavioral Symptoms
Equipment and Supplies
Linear Models
Anxiety
Alzheimer's Disease
Alzheimer
Familial
Prodromal Symptoms
Delusions
Carrier
Appetite
Psychopathology
Psychiatry
Sleep

Keywords

  • Alzheimer
  • behaviour
  • depression
  • familial
  • prodromal

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Ringman, J. M., Liang, L. J., Zhou, Y., Vangala, S., Teng, E., Kremen, S., ... Morris, J. C. (2015). Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain, 138(4), 1036-1045. https://doi.org/10.1093/brain/awv004

Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. / Ringman, John M.; Liang, Li Jung; Zhou, Yan; Vangala, Sitaram; Teng, Edmond; Kremen, Sarah; Wharton, David; Goate, Alison; Marcus, Daniel S.; Farlow, Martin; Ghetti, Bernardino; McDade, Eric; Masters, Colin L.; Mayeux, Richard P.; Rossor, Martin; Salloway, Stephen; Schofield, Peter R.; Cummings, Jeffrey L.; Buckles, Virginia; Bateman, Randall; Morris, John C.

In: Brain, Vol. 138, No. 4, 01.04.2015, p. 1036-1045.

Research output: Contribution to journalArticle

Ringman, JM, Liang, LJ, Zhou, Y, Vangala, S, Teng, E, Kremen, S, Wharton, D, Goate, A, Marcus, DS, Farlow, M, Ghetti, B, McDade, E, Masters, CL, Mayeux, RP, Rossor, M, Salloway, S, Schofield, PR, Cummings, JL, Buckles, V, Bateman, R & Morris, JC 2015, 'Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network', Brain, vol. 138, no. 4, pp. 1036-1045. https://doi.org/10.1093/brain/awv004
Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain. 2015 Apr 1;138(4):1036-1045. https://doi.org/10.1093/brain/awv004
Ringman, John M. ; Liang, Li Jung ; Zhou, Yan ; Vangala, Sitaram ; Teng, Edmond ; Kremen, Sarah ; Wharton, David ; Goate, Alison ; Marcus, Daniel S. ; Farlow, Martin ; Ghetti, Bernardino ; McDade, Eric ; Masters, Colin L. ; Mayeux, Richard P. ; Rossor, Martin ; Salloway, Stephen ; Schofield, Peter R. ; Cummings, Jeffrey L. ; Buckles, Virginia ; Bateman, Randall ; Morris, John C. / Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. In: Brain. 2015 ; Vol. 138, No. 4. pp. 1036-1045.
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