Early collateral and microvascular adaptations to intestinal artery occlusion in rat

Joseph L. Unthank, J. Craig Nixon, Harold M. Burkhart, Steven W. Fath, Michael Dalsing

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The technique to repeatedly observe exactly the same vessels in the rat intestine was used to investigate vascular compensation during the 1st wk after abrupt arterial ligation. A collateral-dependent tissue region was created by ligation of three to four sequential intestinal arteries. At the center of the collateral-dependent region, arterial pressure decreased from 96 ± 3.7 to 29 ± 2.5 mmHg, and intestinal blood flow fell ∼80% during maximal dilation initially postligation. One week later, pressure and blood flow at the center had increased 31 and 250%, respectively. Relative to preligation values, the only compensatory adaptation was an enlargement (31 ± 11%) of the collateral arteries located between normal tissue and the center; no increase was observed in the diameter or numbers of arterioles or collateral arteries at the center. Wall shear rate was increased 173 ± 35% initially postligation at the site where luminal enlargement occurred. The selective enlargement of collateral arteries away from the center region is consistent with the hypothesis that collateral enlargement is induced by chronic increases in wall shear rate and can occur independently of tissue ischemia.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume40
Issue number3
StatePublished - Sep 1996

Fingerprint

Arteries
Ligation
Arterioles
Intestines
Blood Vessels
Dilatation
Arterial Pressure
Ischemia
Blood Pressure

Keywords

  • Arterial insufficiency
  • Arterial occlusion
  • Arterioles
  • Blood flow
  • Collateral development
  • Wall shear rate

ASJC Scopus subject areas

  • Physiology

Cite this

Early collateral and microvascular adaptations to intestinal artery occlusion in rat. / Unthank, Joseph L.; Nixon, J. Craig; Burkhart, Harold M.; Fath, Steven W.; Dalsing, Michael.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 40, No. 3, 09.1996.

Research output: Contribution to journalArticle

@article{45784d29abb647a5830ef2f9c7ff677a,
title = "Early collateral and microvascular adaptations to intestinal artery occlusion in rat",
abstract = "The technique to repeatedly observe exactly the same vessels in the rat intestine was used to investigate vascular compensation during the 1st wk after abrupt arterial ligation. A collateral-dependent tissue region was created by ligation of three to four sequential intestinal arteries. At the center of the collateral-dependent region, arterial pressure decreased from 96 ± 3.7 to 29 ± 2.5 mmHg, and intestinal blood flow fell ∼80{\%} during maximal dilation initially postligation. One week later, pressure and blood flow at the center had increased 31 and 250{\%}, respectively. Relative to preligation values, the only compensatory adaptation was an enlargement (31 ± 11{\%}) of the collateral arteries located between normal tissue and the center; no increase was observed in the diameter or numbers of arterioles or collateral arteries at the center. Wall shear rate was increased 173 ± 35{\%} initially postligation at the site where luminal enlargement occurred. The selective enlargement of collateral arteries away from the center region is consistent with the hypothesis that collateral enlargement is induced by chronic increases in wall shear rate and can occur independently of tissue ischemia.",
keywords = "Arterial insufficiency, Arterial occlusion, Arterioles, Blood flow, Collateral development, Wall shear rate",
author = "Unthank, {Joseph L.} and Nixon, {J. Craig} and Burkhart, {Harold M.} and Fath, {Steven W.} and Michael Dalsing",
year = "1996",
month = "9",
language = "English",
volume = "40",
journal = "American Journal of Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Early collateral and microvascular adaptations to intestinal artery occlusion in rat

AU - Unthank, Joseph L.

AU - Nixon, J. Craig

AU - Burkhart, Harold M.

AU - Fath, Steven W.

AU - Dalsing, Michael

PY - 1996/9

Y1 - 1996/9

N2 - The technique to repeatedly observe exactly the same vessels in the rat intestine was used to investigate vascular compensation during the 1st wk after abrupt arterial ligation. A collateral-dependent tissue region was created by ligation of three to four sequential intestinal arteries. At the center of the collateral-dependent region, arterial pressure decreased from 96 ± 3.7 to 29 ± 2.5 mmHg, and intestinal blood flow fell ∼80% during maximal dilation initially postligation. One week later, pressure and blood flow at the center had increased 31 and 250%, respectively. Relative to preligation values, the only compensatory adaptation was an enlargement (31 ± 11%) of the collateral arteries located between normal tissue and the center; no increase was observed in the diameter or numbers of arterioles or collateral arteries at the center. Wall shear rate was increased 173 ± 35% initially postligation at the site where luminal enlargement occurred. The selective enlargement of collateral arteries away from the center region is consistent with the hypothesis that collateral enlargement is induced by chronic increases in wall shear rate and can occur independently of tissue ischemia.

AB - The technique to repeatedly observe exactly the same vessels in the rat intestine was used to investigate vascular compensation during the 1st wk after abrupt arterial ligation. A collateral-dependent tissue region was created by ligation of three to four sequential intestinal arteries. At the center of the collateral-dependent region, arterial pressure decreased from 96 ± 3.7 to 29 ± 2.5 mmHg, and intestinal blood flow fell ∼80% during maximal dilation initially postligation. One week later, pressure and blood flow at the center had increased 31 and 250%, respectively. Relative to preligation values, the only compensatory adaptation was an enlargement (31 ± 11%) of the collateral arteries located between normal tissue and the center; no increase was observed in the diameter or numbers of arterioles or collateral arteries at the center. Wall shear rate was increased 173 ± 35% initially postligation at the site where luminal enlargement occurred. The selective enlargement of collateral arteries away from the center region is consistent with the hypothesis that collateral enlargement is induced by chronic increases in wall shear rate and can occur independently of tissue ischemia.

KW - Arterial insufficiency

KW - Arterial occlusion

KW - Arterioles

KW - Blood flow

KW - Collateral development

KW - Wall shear rate

UR - http://www.scopus.com/inward/record.url?scp=33750702900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750702900&partnerID=8YFLogxK

M3 - Article

C2 - 8853325

AN - SCOPUS:33750702900

VL - 40

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1857

IS - 3

ER -