Early drop in systolic blood pressure and worsening renal function in acute heart failure

Renal results of Pre-RELAX-AHF

Adriaan A. Voors, Beth A. Davison, G. Michael Felker, Piotr Ponikowski, Elaine Unemori, Gadi Cotter, John R. Teerlink, Barry H. Greenberg, Gerasimos Filippatos, Sam L. Teichman, Marco Metra, M. Metra, J. R. Teerlink, G. M. Felker, A. A. Voors, P. Ponikowski, B. Greenberg, B. A. Davison, S. L. Teichman, E. Unemori & 44 others G. Cotter, B. M. Massie, S. Goldstein, M. Bohm, G. Francis, C. E. Davis, S. Boldueva, V. Moiseev, Z. Shogenov, M. Ruda, A. Vishnevsky, M. Boyarkin, V. Simanenkov, S. Tereschenko, Y. Shwartz, O. Orlikova, M. Arkhipov, I. Libov, R. Sardinov, A. Suvorov, A. Marmor, A. Katz, R. Zimlichman, M. Omary, R. Hershkoviz, S. Goland, A. Keren, Peter Pang, P. Ponikowski, J. Grzybowski, W. Musial, D. Apró, G. Lupkovics, M. Metra, C. Stamate, A. Salajan, A. Matei, P. Levy, P. Pang, S. Collins, D. Gupta, W. Van Mieghem, L. Muyldermans, G. Vervoort

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Aims We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. Methods and resultsThe Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) for AHF and randomized them to relaxin given intravenous (i.v.) for 48 h or placebo. Blood pressure was measured at baseline, at 3, 6, 9, 12, 24, 36, and 48 h and at 3, 4, and 5 days after enrolment. Worsening renal function was defined as a serum creatinine increase of

Original languageEnglish (US)
Pages (from-to)961-967
Number of pages7
JournalEuropean Journal of Heart Failure
Volume13
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Acute Kidney Injury
Heart Failure
Blood Pressure
Kidney
Relaxin
Creatinine
Placebos
Serum

Keywords

  • Acute heart failure
  • Blood pressure
  • Creatinine
  • Mortality
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Voors, A. A., Davison, B. A., Felker, G. M., Ponikowski, P., Unemori, E., Cotter, G., ... Vervoort, G. (2011). Early drop in systolic blood pressure and worsening renal function in acute heart failure: Renal results of Pre-RELAX-AHF. European Journal of Heart Failure, 13(9), 961-967. https://doi.org/10.1093/eurjhf/hfr060

Early drop in systolic blood pressure and worsening renal function in acute heart failure : Renal results of Pre-RELAX-AHF. / Voors, Adriaan A.; Davison, Beth A.; Felker, G. Michael; Ponikowski, Piotr; Unemori, Elaine; Cotter, Gadi; Teerlink, John R.; Greenberg, Barry H.; Filippatos, Gerasimos; Teichman, Sam L.; Metra, Marco; Metra, M.; Teerlink, J. R.; Felker, G. M.; Voors, A. A.; Ponikowski, P.; Greenberg, B.; Davison, B. A.; Teichman, S. L.; Unemori, E.; Cotter, G.; Massie, B. M.; Goldstein, S.; Bohm, M.; Francis, G.; Davis, C. E.; Boldueva, S.; Moiseev, V.; Shogenov, Z.; Ruda, M.; Vishnevsky, A.; Boyarkin, M.; Simanenkov, V.; Tereschenko, S.; Shwartz, Y.; Orlikova, O.; Arkhipov, M.; Libov, I.; Sardinov, R.; Suvorov, A.; Marmor, A.; Katz, A.; Zimlichman, R.; Omary, M.; Hershkoviz, R.; Goland, S.; Keren, A.; Pang, Peter; Ponikowski, P.; Grzybowski, J.; Musial, W.; Apró, D.; Lupkovics, G.; Metra, M.; Stamate, C.; Salajan, A.; Matei, A.; Levy, P.; Pang, P.; Collins, S.; Gupta, D.; Van Mieghem, W.; Muyldermans, L.; Vervoort, G.

In: European Journal of Heart Failure, Vol. 13, No. 9, 09.2011, p. 961-967.

Research output: Contribution to journalArticle

Voors, AA, Davison, BA, Felker, GM, Ponikowski, P, Unemori, E, Cotter, G, Teerlink, JR, Greenberg, BH, Filippatos, G, Teichman, SL, Metra, M, Metra, M, Teerlink, JR, Felker, GM, Voors, AA, Ponikowski, P, Greenberg, B, Davison, BA, Teichman, SL, Unemori, E, Cotter, G, Massie, BM, Goldstein, S, Bohm, M, Francis, G, Davis, CE, Boldueva, S, Moiseev, V, Shogenov, Z, Ruda, M, Vishnevsky, A, Boyarkin, M, Simanenkov, V, Tereschenko, S, Shwartz, Y, Orlikova, O, Arkhipov, M, Libov, I, Sardinov, R, Suvorov, A, Marmor, A, Katz, A, Zimlichman, R, Omary, M, Hershkoviz, R, Goland, S, Keren, A, Pang, P, Ponikowski, P, Grzybowski, J, Musial, W, Apró, D, Lupkovics, G, Metra, M, Stamate, C, Salajan, A, Matei, A, Levy, P, Pang, P, Collins, S, Gupta, D, Van Mieghem, W, Muyldermans, L & Vervoort, G 2011, 'Early drop in systolic blood pressure and worsening renal function in acute heart failure: Renal results of Pre-RELAX-AHF', European Journal of Heart Failure, vol. 13, no. 9, pp. 961-967. https://doi.org/10.1093/eurjhf/hfr060
Voors, Adriaan A. ; Davison, Beth A. ; Felker, G. Michael ; Ponikowski, Piotr ; Unemori, Elaine ; Cotter, Gadi ; Teerlink, John R. ; Greenberg, Barry H. ; Filippatos, Gerasimos ; Teichman, Sam L. ; Metra, Marco ; Metra, M. ; Teerlink, J. R. ; Felker, G. M. ; Voors, A. A. ; Ponikowski, P. ; Greenberg, B. ; Davison, B. A. ; Teichman, S. L. ; Unemori, E. ; Cotter, G. ; Massie, B. M. ; Goldstein, S. ; Bohm, M. ; Francis, G. ; Davis, C. E. ; Boldueva, S. ; Moiseev, V. ; Shogenov, Z. ; Ruda, M. ; Vishnevsky, A. ; Boyarkin, M. ; Simanenkov, V. ; Tereschenko, S. ; Shwartz, Y. ; Orlikova, O. ; Arkhipov, M. ; Libov, I. ; Sardinov, R. ; Suvorov, A. ; Marmor, A. ; Katz, A. ; Zimlichman, R. ; Omary, M. ; Hershkoviz, R. ; Goland, S. ; Keren, A. ; Pang, Peter ; Ponikowski, P. ; Grzybowski, J. ; Musial, W. ; Apró, D. ; Lupkovics, G. ; Metra, M. ; Stamate, C. ; Salajan, A. ; Matei, A. ; Levy, P. ; Pang, P. ; Collins, S. ; Gupta, D. ; Van Mieghem, W. ; Muyldermans, L. ; Vervoort, G. / Early drop in systolic blood pressure and worsening renal function in acute heart failure : Renal results of Pre-RELAX-AHF. In: European Journal of Heart Failure. 2011 ; Vol. 13, No. 9. pp. 961-967.
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T2 - Renal results of Pre-RELAX-AHF

AU - Voors, Adriaan A.

AU - Davison, Beth A.

AU - Felker, G. Michael

AU - Ponikowski, Piotr

AU - Unemori, Elaine

AU - Cotter, Gadi

AU - Teerlink, John R.

AU - Greenberg, Barry H.

AU - Filippatos, Gerasimos

AU - Teichman, Sam L.

AU - Metra, Marco

AU - Metra, M.

AU - Teerlink, J. R.

AU - Felker, G. M.

AU - Voors, A. A.

AU - Ponikowski, P.

AU - Greenberg, B.

AU - Davison, B. A.

AU - Teichman, S. L.

AU - Unemori, E.

AU - Cotter, G.

AU - Massie, B. M.

AU - Goldstein, S.

AU - Bohm, M.

AU - Francis, G.

AU - Davis, C. E.

AU - Boldueva, S.

AU - Moiseev, V.

AU - Shogenov, Z.

AU - Ruda, M.

AU - Vishnevsky, A.

AU - Boyarkin, M.

AU - Simanenkov, V.

AU - Tereschenko, S.

AU - Shwartz, Y.

AU - Orlikova, O.

AU - Arkhipov, M.

AU - Libov, I.

AU - Sardinov, R.

AU - Suvorov, A.

AU - Marmor, A.

AU - Katz, A.

AU - Zimlichman, R.

AU - Omary, M.

AU - Hershkoviz, R.

AU - Goland, S.

AU - Keren, A.

AU - Pang, Peter

AU - Ponikowski, P.

AU - Grzybowski, J.

AU - Musial, W.

AU - Apró, D.

AU - Lupkovics, G.

AU - Metra, M.

AU - Stamate, C.

AU - Salajan, A.

AU - Matei, A.

AU - Levy, P.

AU - Pang, P.

AU - Collins, S.

AU - Gupta, D.

AU - Van Mieghem, W.

AU - Muyldermans, L.

AU - Vervoort, G.

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KW - Acute heart failure

KW - Blood pressure

KW - Creatinine

KW - Mortality

KW - Renal function

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