Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism

Elizabeth P. Hayden, Lea R. Dougherty, Bryan Maloney, Thomas M. Olino, Haroon Sheikh, C. Emily Durbin, John I. Nurnberger, Debomoy K. Lahiri, Daniel N. Klein

Research output: Contribution to journalArticle

49 Scopus citations


Background: Serotonin transporter promoter (5-HTTLPR) genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. Method: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. Results: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. Limitations: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. Conclusions: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalJournal of Affective Disorders
Issue number1-3
StatePublished - Apr 1 2008


  • 5-HTTLPR
  • Depression
  • Depressogenic cognitive style

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Fingerprint Dive into the research topics of 'Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism'. Together they form a unique fingerprint.

  • Cite this