Early events in ischemic renal failure in the rat

Effects of antioxidant therapy

J. E. Bird, Andrew Evan, O. W. Peterson, R. C. Blantz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Renal ischemia followed by two hours of reperfusion produces a complex form of acute renal failure characterized by a reduction in nephron filtration rate (SNGFR) and moderate proximal tubular damage. We have examined glomerular hemodynamics. SNGFR and histologic changes after renal ischemia and two hours of reperfusion in untreated (I) rats and rats pretreated with the antioxidant, probucol (IP). SNGFR decreased significantly by 47% in I rats. Reduction in SNGFR was primarily the results of a major decrease in the glomerular capillary hydrostatic pressure gradient, ΔP, and a decrease in nephron plasma flow (SNPF). The glomerular ultrafiltration coefficient remained equal to control valves. In IP rats SNGFR was improved to values 89% of control rats due to higher values of ΔP and SNPF. Histologic evidence of modest damage to cells of the proximal tubule was equal in both untreated and probucol treated ischemic animals. These studies demonstrate that: (a) primary reduction in nephron filtration rate at the glomerulus results from decreases in ΔP and nephron plasma flow; b) pretreatment with the antioxidant, probucol, increases nephron plasma flow and SNGFR, and maintains more normal values for ΔP; and c) tubular damage was equivalent in I and IP rats in spite of differences in SNGFR.

Original languageEnglish (US)
Pages (from-to)1282-1289
Number of pages8
JournalKidney International
Volume35
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Nephrons
Renal Insufficiency
Antioxidants
Probucol
Reperfusion
Therapeutics
Ischemia
Kidney
Hydrostatic Pressure
Ultrafiltration
Acute Kidney Injury
Reference Values
Hemodynamics

ASJC Scopus subject areas

  • Nephrology

Cite this

Bird, J. E., Evan, A., Peterson, O. W., & Blantz, R. C. (1989). Early events in ischemic renal failure in the rat: Effects of antioxidant therapy. Kidney International, 35(6), 1282-1289.

Early events in ischemic renal failure in the rat : Effects of antioxidant therapy. / Bird, J. E.; Evan, Andrew; Peterson, O. W.; Blantz, R. C.

In: Kidney International, Vol. 35, No. 6, 1989, p. 1282-1289.

Research output: Contribution to journalArticle

Bird, JE, Evan, A, Peterson, OW & Blantz, RC 1989, 'Early events in ischemic renal failure in the rat: Effects of antioxidant therapy', Kidney International, vol. 35, no. 6, pp. 1282-1289.
Bird, J. E. ; Evan, Andrew ; Peterson, O. W. ; Blantz, R. C. / Early events in ischemic renal failure in the rat : Effects of antioxidant therapy. In: Kidney International. 1989 ; Vol. 35, No. 6. pp. 1282-1289.
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