Early-life events may trigger biochemical pathways for Alzheimer's disease: The "LEARn" model

Debomoy Lahiri, Nasser H. Zawia, Nigel H. Greig, Kumar Sambamurti, Bryan Maloney

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Alzheimer's disease (AD), the most common form of dementia among the elderly, manifests mostly late in adult life. However, it is presently unclear when the disease process starts and how long the pathobiochemical processes take to develop. Our goal is to address the timing and nature of triggers that lead to AD. To explain the etiology of AD, we have recently proposed a "Latent Early-life Associated Regulation" (LEARn) model, which postulates a latent expression of specific genes triggered at the developmental stage. This model integrates both the neuropathological features (e.g., amyloid-loaded plaques and tau-laden tangles) and environmental factors (e.g., diet, metal exposure, and hormones) associated with the disease. Environmental agents perturb gene regulation in a long-term fashion, beginning at early developmental stages, but these perturbations do not have pathological results until significantly later in life. The LEARn model operates through the regulatory region (promoter) of the gene and by affecting the methylation status within the promoter of specific genes.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalBiogerontology
Volume9
Issue number6
DOIs
StatePublished - 2008

Fingerprint

Alzheimer Disease
Genes
Nucleic Acid Regulatory Sequences
Amyloid Plaques
Methylation
Dementia
Metals
Hormones
Diet
Gene Expression

Keywords

  • Amyloid
  • Epigenetic
  • Gene regulation
  • Latency
  • Lead
  • Methylation
  • Pb

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Aging

Cite this

Early-life events may trigger biochemical pathways for Alzheimer's disease : The "LEARn" model. / Lahiri, Debomoy; Zawia, Nasser H.; Greig, Nigel H.; Sambamurti, Kumar; Maloney, Bryan.

In: Biogerontology, Vol. 9, No. 6, 2008, p. 375-379.

Research output: Contribution to journalArticle

Lahiri, Debomoy ; Zawia, Nasser H. ; Greig, Nigel H. ; Sambamurti, Kumar ; Maloney, Bryan. / Early-life events may trigger biochemical pathways for Alzheimer's disease : The "LEARn" model. In: Biogerontology. 2008 ; Vol. 9, No. 6. pp. 375-379.
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