Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project

Wei Perng, Marcela Tamayo-Ortiz, Lu Tang, Brisa N. Sánchez, Alejandra Cantoral, John D. Meeker, Dana C. Dolinoy, Elizabeth F. Roberts, Esperanza Martinez Mier, Hector Lamadrid-Figueroa, Peter X.K. Song, Adrienne S. Ettinger, Robert Wright, Manish Arora, Lourdes Schnaas, Deborah J. Watkins, Jaclyn M. Goodrich, Robin C. Garcia, Maritsa Solano-Gonzalez, Luis F. Bautista-ArredondoAdriana Mercado-Garcia, Howard Hu, Mauricio Hernandez-Avila, Martha Maria Tellez-Rojo, Karen E. Peterson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother-child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure other prenatal exposures, banking of DNA and rigorous measurement of a diverse array of outcomes, ELEMENT has since evolved into a major resource for research on early life exposures and developmental outcomes. Participants n=1643 mother-child pairs sequentially recruited (between 1994 and 2003) during pregnancy or at delivery from maternity hospitals in Mexico City, Mexico. Findings to date Maternal bone (eg, patella, tibia) is an endogenous source for fetal lead exposure due to mobilisation of stored lead into circulation during pregnancy and lactation, leading to increased risk of miscarriage, low birth weight and smaller head circumference, and transfer of lead into breastmilk. Daily supplementation with 1200 mg of elemental calcium during pregnancy and lactation reduces lead resorption from maternal bone and thereby, levels of circulating lead. Beyond perinatal outcomes, early life exposure to lead is associated with neurocognitive deficits, behavioural disorders, higher blood pressure and lower weight in offspring during childhood. Some of these relationships were modified by dietary factors; genetic polymorphisms specific for iron, folate and lipid metabolism; and timing of exposure. Research has also expanded to include findings published on other toxicants such as those associated with personal care products and plastics (eg, phthalates, bisphenol A), other metals (eg, mercury, manganese, cadmium), pesticides (organophosphates) and fluoride; other biomarkers (eg, toxicant levels in plasma, hair and teeth); other outcomes (eg, sexual maturation, metabolic syndrome, dental caries); and identification of novel mechanisms via epigenetic and metabolomics profiling. Future plans As the ELEMENT mothers and children age, we plan to (1) continue studying the long-term consequences of toxicant exposure during the perinatal period on adolescent and young adult outcomes as well as outcomes related to the original ELEMENT mothers, such as their metabolic and bone health during perimenopause; and (2) follow the third generation of participants (children of the children) to study intergenerational effects of in utero exposures. Trial registration number NCT00558623.

Original languageEnglish (US)
Article numbere030427
JournalBMJ Open
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Mexico
Mothers
Pregnancy
Lactation
Bone and Bones
Perimenopause
Calcium
Sexual Maturation
Maternity Hospitals
Metabolomics
Patella
Organophosphates
Health
Dental Caries
Low Birth Weight Infant
Spontaneous Abortion
Genetic Polymorphisms
Bone Resorption
Manganese
Lead

Keywords

  • lead
  • Mexico
  • neurocognitive development
  • obesity
  • perinatal

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perng, W., Tamayo-Ortiz, M., Tang, L., Sánchez, B. N., Cantoral, A., Meeker, J. D., ... Peterson, K. E. (2019). Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project. BMJ Open, 9(8), [e030427]. https://doi.org/10.1136/bmjopen-2019-030427

Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project. / Perng, Wei; Tamayo-Ortiz, Marcela; Tang, Lu; Sánchez, Brisa N.; Cantoral, Alejandra; Meeker, John D.; Dolinoy, Dana C.; Roberts, Elizabeth F.; Martinez Mier, Esperanza; Lamadrid-Figueroa, Hector; Song, Peter X.K.; Ettinger, Adrienne S.; Wright, Robert; Arora, Manish; Schnaas, Lourdes; Watkins, Deborah J.; Goodrich, Jaclyn M.; Garcia, Robin C.; Solano-Gonzalez, Maritsa; Bautista-Arredondo, Luis F.; Mercado-Garcia, Adriana; Hu, Howard; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria; Peterson, Karen E.

In: BMJ Open, Vol. 9, No. 8, e030427, 01.08.2019.

Research output: Contribution to journalArticle

Perng, W, Tamayo-Ortiz, M, Tang, L, Sánchez, BN, Cantoral, A, Meeker, JD, Dolinoy, DC, Roberts, EF, Martinez Mier, E, Lamadrid-Figueroa, H, Song, PXK, Ettinger, AS, Wright, R, Arora, M, Schnaas, L, Watkins, DJ, Goodrich, JM, Garcia, RC, Solano-Gonzalez, M, Bautista-Arredondo, LF, Mercado-Garcia, A, Hu, H, Hernandez-Avila, M, Tellez-Rojo, MM & Peterson, KE 2019, 'Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project', BMJ Open, vol. 9, no. 8, e030427. https://doi.org/10.1136/bmjopen-2019-030427
Perng W, Tamayo-Ortiz M, Tang L, Sánchez BN, Cantoral A, Meeker JD et al. Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project. BMJ Open. 2019 Aug 1;9(8). e030427. https://doi.org/10.1136/bmjopen-2019-030427
Perng, Wei ; Tamayo-Ortiz, Marcela ; Tang, Lu ; Sánchez, Brisa N. ; Cantoral, Alejandra ; Meeker, John D. ; Dolinoy, Dana C. ; Roberts, Elizabeth F. ; Martinez Mier, Esperanza ; Lamadrid-Figueroa, Hector ; Song, Peter X.K. ; Ettinger, Adrienne S. ; Wright, Robert ; Arora, Manish ; Schnaas, Lourdes ; Watkins, Deborah J. ; Goodrich, Jaclyn M. ; Garcia, Robin C. ; Solano-Gonzalez, Maritsa ; Bautista-Arredondo, Luis F. ; Mercado-Garcia, Adriana ; Hu, Howard ; Hernandez-Avila, Mauricio ; Tellez-Rojo, Martha Maria ; Peterson, Karen E. / Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project. In: BMJ Open. 2019 ; Vol. 9, No. 8.
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AU - Perng, Wei

AU - Tamayo-Ortiz, Marcela

AU - Tang, Lu

AU - Sánchez, Brisa N.

AU - Cantoral, Alejandra

AU - Meeker, John D.

AU - Dolinoy, Dana C.

AU - Roberts, Elizabeth F.

AU - Martinez Mier, Esperanza

AU - Lamadrid-Figueroa, Hector

AU - Song, Peter X.K.

AU - Ettinger, Adrienne S.

AU - Wright, Robert

AU - Arora, Manish

AU - Schnaas, Lourdes

AU - Watkins, Deborah J.

AU - Goodrich, Jaclyn M.

AU - Garcia, Robin C.

AU - Solano-Gonzalez, Maritsa

AU - Bautista-Arredondo, Luis F.

AU - Mercado-Garcia, Adriana

AU - Hu, Howard

AU - Hernandez-Avila, Mauricio

AU - Tellez-Rojo, Martha Maria

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N2 - Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother-child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure other prenatal exposures, banking of DNA and rigorous measurement of a diverse array of outcomes, ELEMENT has since evolved into a major resource for research on early life exposures and developmental outcomes. Participants n=1643 mother-child pairs sequentially recruited (between 1994 and 2003) during pregnancy or at delivery from maternity hospitals in Mexico City, Mexico. Findings to date Maternal bone (eg, patella, tibia) is an endogenous source for fetal lead exposure due to mobilisation of stored lead into circulation during pregnancy and lactation, leading to increased risk of miscarriage, low birth weight and smaller head circumference, and transfer of lead into breastmilk. Daily supplementation with 1200 mg of elemental calcium during pregnancy and lactation reduces lead resorption from maternal bone and thereby, levels of circulating lead. Beyond perinatal outcomes, early life exposure to lead is associated with neurocognitive deficits, behavioural disorders, higher blood pressure and lower weight in offspring during childhood. Some of these relationships were modified by dietary factors; genetic polymorphisms specific for iron, folate and lipid metabolism; and timing of exposure. Research has also expanded to include findings published on other toxicants such as those associated with personal care products and plastics (eg, phthalates, bisphenol A), other metals (eg, mercury, manganese, cadmium), pesticides (organophosphates) and fluoride; other biomarkers (eg, toxicant levels in plasma, hair and teeth); other outcomes (eg, sexual maturation, metabolic syndrome, dental caries); and identification of novel mechanisms via epigenetic and metabolomics profiling. Future plans As the ELEMENT mothers and children age, we plan to (1) continue studying the long-term consequences of toxicant exposure during the perinatal period on adolescent and young adult outcomes as well as outcomes related to the original ELEMENT mothers, such as their metabolic and bone health during perimenopause; and (2) follow the third generation of participants (children of the children) to study intergenerational effects of in utero exposures. Trial registration number NCT00558623.

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