Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity

Deborah K. VanderVeen, Camilia R. Martin, Reshma Mehendale, Elizabeth N. Allred, Olaf Dammann, Alan Leviton, Bavesh Shah, William Seefield, Linda J. Van Marter, Robert M. Insoft, Tony Fraioli, Cynthia Cole, John M. Fiascone, Caroline Baumal, Francis Bednarek, Robert Gise, Richard Ehrenkranz, Kathleen Stoessel, T. Michael O'Shea, Grey WeaverStephen C. Engelke, Elaine Price Schwartz, Carl Bose, David K. Wallace, Mariel Poortenga, Patrick Droste, I. Nicholas Olomu, Linda Angell, Nigel Paneth, Padmani Karna, Michael D. Schreiber, Ahmed Abdelsalam, Kourous Rezaei, Daniel Batton, Michael Trese, Antonio Capone

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To identify nutritional and weight gain limitations associated with retinopathy of prematurity (ROP) severity among very preterm newborns. Patients and Methods:1180 infants <28 weeks GA at birth with ROP examination results were grouped and analyzed by quartile of weekly total calorie, carbohydrate, protein, and lipid intake, as well as growth velocity between postnatal days 7 and 28 (adjusted for GA and birth weight Z-score). ROP was categorized by development of no, mild (<prethreshold), type 2, or type 1 ROP, as well as markers of ROP severity including stage 3 ROP, zone 1 disease, and plus disease. Associations between nutritional intake and ROP severity were compared. Results: Greater risk for Type 1 ROP (risk/95% confidence intervals) was found for infants with lowest quartile receipt of lipids (2.1/1.1, 3.8), total calories (2.2/1.4, 3.6), and carbohydrates (1.7/1.1, 2.9). Development of zone 1 ROP was associated with lipid or total calorie intake in the lowest quartile, and development of stage 3 ROP was associated with lowest quartile of total calorie intake. Growth velocity in the lowest quartile was associated with increased risk of any ROP, including type 1 ROP. Conclusion: The risk of developing severe ROP in extremely premature infants might be reduced by improving nutritional support, specifically targeting lipids and total calories, and perhaps by improving weight gain.

Original languageEnglish (US)
Article numbere64325
JournalPLoS ONE
Volume8
Issue number5
DOIs
StatePublished - May 29 2013
Externally publishedYes

Fingerprint

premature birth
retinal diseases
Retinopathy of Prematurity
Nutrition
Weight Gain
neonates
weight gain
Newborn Infant
nutrition
Lipids
Carbohydrates
energy intake
lipids
Extremely Premature Infants
Proteins
carbohydrate intake
Nutritional Support
nutritional support
fat intake
Growth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

VanderVeen, D. K., Martin, C. R., Mehendale, R., Allred, E. N., Dammann, O., Leviton, A., ... Capone, A. (2013). Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity. PLoS ONE, 8(5), [e64325]. https://doi.org/10.1371/journal.pone.0064325

Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity. / VanderVeen, Deborah K.; Martin, Camilia R.; Mehendale, Reshma; Allred, Elizabeth N.; Dammann, Olaf; Leviton, Alan; Shah, Bavesh; Seefield, William; Van Marter, Linda J.; Insoft, Robert M.; Fraioli, Tony; Cole, Cynthia; Fiascone, John M.; Baumal, Caroline; Bednarek, Francis; Gise, Robert; Ehrenkranz, Richard; Stoessel, Kathleen; O'Shea, T. Michael; Weaver, Grey; Engelke, Stephen C.; Schwartz, Elaine Price; Bose, Carl; Wallace, David K.; Poortenga, Mariel; Droste, Patrick; Olomu, I. Nicholas; Angell, Linda; Paneth, Nigel; Karna, Padmani; Schreiber, Michael D.; Abdelsalam, Ahmed; Rezaei, Kourous; Batton, Daniel; Trese, Michael; Capone, Antonio.

In: PLoS ONE, Vol. 8, No. 5, e64325, 29.05.2013.

Research output: Contribution to journalArticle

VanderVeen, DK, Martin, CR, Mehendale, R, Allred, EN, Dammann, O, Leviton, A, Shah, B, Seefield, W, Van Marter, LJ, Insoft, RM, Fraioli, T, Cole, C, Fiascone, JM, Baumal, C, Bednarek, F, Gise, R, Ehrenkranz, R, Stoessel, K, O'Shea, TM, Weaver, G, Engelke, SC, Schwartz, EP, Bose, C, Wallace, DK, Poortenga, M, Droste, P, Olomu, IN, Angell, L, Paneth, N, Karna, P, Schreiber, MD, Abdelsalam, A, Rezaei, K, Batton, D, Trese, M & Capone, A 2013, 'Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity', PLoS ONE, vol. 8, no. 5, e64325. https://doi.org/10.1371/journal.pone.0064325
VanderVeen DK, Martin CR, Mehendale R, Allred EN, Dammann O, Leviton A et al. Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity. PLoS ONE. 2013 May 29;8(5). e64325. https://doi.org/10.1371/journal.pone.0064325
VanderVeen, Deborah K. ; Martin, Camilia R. ; Mehendale, Reshma ; Allred, Elizabeth N. ; Dammann, Olaf ; Leviton, Alan ; Shah, Bavesh ; Seefield, William ; Van Marter, Linda J. ; Insoft, Robert M. ; Fraioli, Tony ; Cole, Cynthia ; Fiascone, John M. ; Baumal, Caroline ; Bednarek, Francis ; Gise, Robert ; Ehrenkranz, Richard ; Stoessel, Kathleen ; O'Shea, T. Michael ; Weaver, Grey ; Engelke, Stephen C. ; Schwartz, Elaine Price ; Bose, Carl ; Wallace, David K. ; Poortenga, Mariel ; Droste, Patrick ; Olomu, I. Nicholas ; Angell, Linda ; Paneth, Nigel ; Karna, Padmani ; Schreiber, Michael D. ; Abdelsalam, Ahmed ; Rezaei, Kourous ; Batton, Daniel ; Trese, Michael ; Capone, Antonio. / Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity. In: PLoS ONE. 2013 ; Vol. 8, No. 5.
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AU - Dammann, Olaf

AU - Leviton, Alan

AU - Shah, Bavesh

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AU - Abdelsalam, Ahmed

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AU - Trese, Michael

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