Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults

Trajectories of Frontal Theta Oscillations During a Go/No-Go Task

Jacquelyn Meyers, Vivia V. McCutcheon, Ashwini K. Pandey, Chella Kamarajan, Stacey Subbie, David Chorlian, Jessica Salvatore, Gayathri Pandey, Laura Almasy, Andrey Anokhin, Lance Bauer, Annah Bender, Danielle M. Dick, Howard Edenberg, Victor Hesselbrock, John Kramer, Samuel Kuperman, Arpana Agrawal, Kathleen Bucholz, Bernice Porjesz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. Method: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Data were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort, composed of offspring who were aged 12 through 22 years at enrollment from high-risk and comparison families, with follow-ups at 2-year intervals since 2004. In addition, other important predictors of neurophysiologic functioning (eg, substance use, impulsivity, and parental alcohol use disorders) were investigated. Moreover, associations of neurophysiologic functioning with alcohol and cannabis use disorder symptom counts and externalizing and internalizing psychopathology were examined. Results: Individuals exposed to sexual assaultive trauma before 10 years of age had slower rates of change in developmental trajectories of no-go frontal theta during response inhibition. Importantly, effects remained significant after accounting for exposure to other traumatic exposures, such as parental history of alcohol use disorder and participants’ substance use, but not measures of impulsivity. Further, slower rates of change in no-go frontal theta adolescent and young adult development were associated with increased risk for alcohol use disorder symptoms and internalizing psychopathology, but not for cannabis use disorder symptoms or externalizing psychopathology. Conclusion: Childhood sexual assault is associated with atypical frontal neurophysiologic development during response inhibition. This could reflect alterations in frontal lobe development, synaptic pruning, and/or cortical maturation involving neural circuits for inhibitory control. These same areas could be associated with increased risk for young adult alcohol use disorder symptoms and internalizing psychopathology. These findings support the hypothesis that changes in neurocognitive development related to early sexual trauma exposure could increase the risk for mental health and substance use problems in young adulthood.

Original languageEnglish (US)
Pages (from-to)242-255.e2
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume58
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Neural Inhibition
Psychopathology
Young Adult
Alcohols
Wounds and Injuries
Substance-Related Disorders
Impulsive Behavior
Cannabis
Neuronal Plasticity
Frontal Lobe
Alcoholism
Mental Health
Brain
Inhibition (Psychology)

Keywords

  • alcohol dependence
  • event-related oscillations
  • inhibition
  • internalizing
  • sexual abuse

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults : Trajectories of Frontal Theta Oscillations During a Go/No-Go Task. / Meyers, Jacquelyn; McCutcheon, Vivia V.; Pandey, Ashwini K.; Kamarajan, Chella; Subbie, Stacey; Chorlian, David; Salvatore, Jessica; Pandey, Gayathri; Almasy, Laura; Anokhin, Andrey; Bauer, Lance; Bender, Annah; Dick, Danielle M.; Edenberg, Howard; Hesselbrock, Victor; Kramer, John; Kuperman, Samuel; Agrawal, Arpana; Bucholz, Kathleen; Porjesz, Bernice.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 58, No. 2, 01.02.2019, p. 242-255.e2.

Research output: Contribution to journalArticle

Meyers, J, McCutcheon, VV, Pandey, AK, Kamarajan, C, Subbie, S, Chorlian, D, Salvatore, J, Pandey, G, Almasy, L, Anokhin, A, Bauer, L, Bender, A, Dick, DM, Edenberg, H, Hesselbrock, V, Kramer, J, Kuperman, S, Agrawal, A, Bucholz, K & Porjesz, B 2019, 'Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 58, no. 2, pp. 242-255.e2. https://doi.org/10.1016/j.jaac.2018.07.905
Meyers, Jacquelyn ; McCutcheon, Vivia V. ; Pandey, Ashwini K. ; Kamarajan, Chella ; Subbie, Stacey ; Chorlian, David ; Salvatore, Jessica ; Pandey, Gayathri ; Almasy, Laura ; Anokhin, Andrey ; Bauer, Lance ; Bender, Annah ; Dick, Danielle M. ; Edenberg, Howard ; Hesselbrock, Victor ; Kramer, John ; Kuperman, Samuel ; Agrawal, Arpana ; Bucholz, Kathleen ; Porjesz, Bernice. / Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults : Trajectories of Frontal Theta Oscillations During a Go/No-Go Task. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2019 ; Vol. 58, No. 2. pp. 242-255.e2.
@article{8eca9096922a4a2f8a7c67ce4156992a,
title = "Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task",
abstract = "Objective: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. Method: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Data were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort, composed of offspring who were aged 12 through 22 years at enrollment from high-risk and comparison families, with follow-ups at 2-year intervals since 2004. In addition, other important predictors of neurophysiologic functioning (eg, substance use, impulsivity, and parental alcohol use disorders) were investigated. Moreover, associations of neurophysiologic functioning with alcohol and cannabis use disorder symptom counts and externalizing and internalizing psychopathology were examined. Results: Individuals exposed to sexual assaultive trauma before 10 years of age had slower rates of change in developmental trajectories of no-go frontal theta during response inhibition. Importantly, effects remained significant after accounting for exposure to other traumatic exposures, such as parental history of alcohol use disorder and participants’ substance use, but not measures of impulsivity. Further, slower rates of change in no-go frontal theta adolescent and young adult development were associated with increased risk for alcohol use disorder symptoms and internalizing psychopathology, but not for cannabis use disorder symptoms or externalizing psychopathology. Conclusion: Childhood sexual assault is associated with atypical frontal neurophysiologic development during response inhibition. This could reflect alterations in frontal lobe development, synaptic pruning, and/or cortical maturation involving neural circuits for inhibitory control. These same areas could be associated with increased risk for young adult alcohol use disorder symptoms and internalizing psychopathology. These findings support the hypothesis that changes in neurocognitive development related to early sexual trauma exposure could increase the risk for mental health and substance use problems in young adulthood.",
keywords = "alcohol dependence, event-related oscillations, inhibition, internalizing, sexual abuse",
author = "Jacquelyn Meyers and McCutcheon, {Vivia V.} and Pandey, {Ashwini K.} and Chella Kamarajan and Stacey Subbie and David Chorlian and Jessica Salvatore and Gayathri Pandey and Laura Almasy and Andrey Anokhin and Lance Bauer and Annah Bender and Dick, {Danielle M.} and Howard Edenberg and Victor Hesselbrock and John Kramer and Samuel Kuperman and Arpana Agrawal and Kathleen Bucholz and Bernice Porjesz",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.jaac.2018.07.905",
language = "English (US)",
volume = "58",
pages = "242--255.e2",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults

T2 - Trajectories of Frontal Theta Oscillations During a Go/No-Go Task

AU - Meyers, Jacquelyn

AU - McCutcheon, Vivia V.

AU - Pandey, Ashwini K.

AU - Kamarajan, Chella

AU - Subbie, Stacey

AU - Chorlian, David

AU - Salvatore, Jessica

AU - Pandey, Gayathri

AU - Almasy, Laura

AU - Anokhin, Andrey

AU - Bauer, Lance

AU - Bender, Annah

AU - Dick, Danielle M.

AU - Edenberg, Howard

AU - Hesselbrock, Victor

AU - Kramer, John

AU - Kuperman, Samuel

AU - Agrawal, Arpana

AU - Bucholz, Kathleen

AU - Porjesz, Bernice

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Objective: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. Method: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Data were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort, composed of offspring who were aged 12 through 22 years at enrollment from high-risk and comparison families, with follow-ups at 2-year intervals since 2004. In addition, other important predictors of neurophysiologic functioning (eg, substance use, impulsivity, and parental alcohol use disorders) were investigated. Moreover, associations of neurophysiologic functioning with alcohol and cannabis use disorder symptom counts and externalizing and internalizing psychopathology were examined. Results: Individuals exposed to sexual assaultive trauma before 10 years of age had slower rates of change in developmental trajectories of no-go frontal theta during response inhibition. Importantly, effects remained significant after accounting for exposure to other traumatic exposures, such as parental history of alcohol use disorder and participants’ substance use, but not measures of impulsivity. Further, slower rates of change in no-go frontal theta adolescent and young adult development were associated with increased risk for alcohol use disorder symptoms and internalizing psychopathology, but not for cannabis use disorder symptoms or externalizing psychopathology. Conclusion: Childhood sexual assault is associated with atypical frontal neurophysiologic development during response inhibition. This could reflect alterations in frontal lobe development, synaptic pruning, and/or cortical maturation involving neural circuits for inhibitory control. These same areas could be associated with increased risk for young adult alcohol use disorder symptoms and internalizing psychopathology. These findings support the hypothesis that changes in neurocognitive development related to early sexual trauma exposure could increase the risk for mental health and substance use problems in young adulthood.

AB - Objective: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. Method: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Data were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort, composed of offspring who were aged 12 through 22 years at enrollment from high-risk and comparison families, with follow-ups at 2-year intervals since 2004. In addition, other important predictors of neurophysiologic functioning (eg, substance use, impulsivity, and parental alcohol use disorders) were investigated. Moreover, associations of neurophysiologic functioning with alcohol and cannabis use disorder symptom counts and externalizing and internalizing psychopathology were examined. Results: Individuals exposed to sexual assaultive trauma before 10 years of age had slower rates of change in developmental trajectories of no-go frontal theta during response inhibition. Importantly, effects remained significant after accounting for exposure to other traumatic exposures, such as parental history of alcohol use disorder and participants’ substance use, but not measures of impulsivity. Further, slower rates of change in no-go frontal theta adolescent and young adult development were associated with increased risk for alcohol use disorder symptoms and internalizing psychopathology, but not for cannabis use disorder symptoms or externalizing psychopathology. Conclusion: Childhood sexual assault is associated with atypical frontal neurophysiologic development during response inhibition. This could reflect alterations in frontal lobe development, synaptic pruning, and/or cortical maturation involving neural circuits for inhibitory control. These same areas could be associated with increased risk for young adult alcohol use disorder symptoms and internalizing psychopathology. These findings support the hypothesis that changes in neurocognitive development related to early sexual trauma exposure could increase the risk for mental health and substance use problems in young adulthood.

KW - alcohol dependence

KW - event-related oscillations

KW - inhibition

KW - internalizing

KW - sexual abuse

UR - http://www.scopus.com/inward/record.url?scp=85061065872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061065872&partnerID=8YFLogxK

U2 - 10.1016/j.jaac.2018.07.905

DO - 10.1016/j.jaac.2018.07.905

M3 - Article

VL - 58

SP - 242-255.e2

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 2

ER -