Early Treatment in Emergency Department Patients with Acute Heart Failure: Does Time Matter?

Anna Marie Chang, Peter S. Pang, Javed Butler, Alan B. Storrow, Phillip D. Levy, Jo Ann Lindenfeld, Sean P. Collins

Research output: Contribution to journalReview article


Purpose of Review: Acute heart failure accounts for over one million hospital discharges annually. Current guidelines suggest treatments for AHF should begin “without delay” but this time interval has not been clearly defined. Recent Findings: Data suggest that certain treatments such as earlier treatment with diuretics and vasodilators may improve patient symptom relief, morbidity, and mortality. Secondary analyses of clinical trials of novel treatments under development have not shown similar results. Summary: The data are equivocal regarding the impact of early treatment in AHF on in-hospital and long-term morbidity and mortality. Improved clinical trial designs will help answer when and if “early” treatment should begin and whether it impacts short- and long-term outcomes in AHF.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalCurrent Heart Failure Reports
Issue number1
StatePublished - Feb 15 2019



  • Acute heart failure
  • Emergency medicine
  • Treatments for AHF

ASJC Scopus subject areas

  • Emergency Medicine
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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