EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor–Positive Breast Cancer

Steven A. Buechler, Yesim Gökmen-Polar, Sunil S. Badve

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Currently available molecular signatures assess the risk of recurrence and the benefit of chemotherapy; however, these tests may have large intermediate risk groups, limiting their usefulness. We describe a novel 5-gene signature that is a robust prognostic assay that performed similarly to currently available signatures in concordance analyses. However, it identified significantly fewer patients as intermediate risk and more as low risk than currently available assays.

Original languageEnglish (US)
Pages (from-to)17-26.e8
JournalClinical breast cancer
Volume19
Issue number1
DOIs
StatePublished - Feb 2019

Keywords

  • Estrogen receptor-positive
  • Gene signature
  • Molecular diagnostic
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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