Ectopic prostatic tissue: Histogenesis and histopathological characteristics

Shams Halat, John N. Eble, David J. Grignon, Shannon Lacy, Rodolfo Montironi, Gregory T. Maclennan, Antonio Lopez-Beltran, Puay Hoon Tan, Lee A. Baldridge, Liang Cheng

Research output: Contribution to journalArticle

21 Scopus citations


Aims: To evaluate the histological and immunohistochemical characteristics of ectopic prostatic tissue. Methods and results: We studied 20 cases of ectopic prostate. In 85% (17/20) of the cases, the ectopic prostatic tissue was located in the bladder; in the remaining cases, it was located in the urethra. In 60% of the cases (12/20), no significant inflammatory or reactive/reparative changes were identified in the adjacent tissue. Immunohistochemical stains for prostate-specific antigen, prostate-specific acid phosphatase, and prostein were positive in the glandular epithelial cells of all cases. Stains for 34βE12 and p63 confirmed the presence of basal cells in all cases. There was no overexpression of α-methylacyl-CoA racemase in any of the cases. There was cytoplasmic luminal staining for CD10 and cytoplasmic staining for cytokeratin 18 in acinar cells in all cases. In cases in which followup data were available, no patient was found to have residual or recurrent ectopic prostatic tissue and none developed prostatic adenocarcinoma. Conclusions: Ectopic prostatic tissue is occasionally encountered in the lower urinary tract, most commonly in the bladder and urethra of males. Ectopic prostatic tissue has histological and immunohistochemical characteristics that are indistinguishable from those of normal prostatic tissue, and most likely represents the persistence of embryonic structures.

Original languageEnglish (US)
Pages (from-to)750-758
Number of pages9
Issue number5
StatePublished - Apr 1 2011


  • Biomarkers
  • Differential diagnosis
  • Ectopic prostate
  • Genitourinary tract
  • Histogenesis
  • Polyps
  • Prostate
  • Urinary bladder

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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  • Cite this

    Halat, S., Eble, J. N., Grignon, D. J., Lacy, S., Montironi, R., Maclennan, G. T., Lopez-Beltran, A., Tan, P. H., Baldridge, L. A., & Cheng, L. (2011). Ectopic prostatic tissue: Histogenesis and histopathological characteristics. Histopathology, 58(5), 750-758.