EEG synchronization deficits in schizophrenia spectrum disorders

Brian O'Donnell, M. A. Wilt, C. A. Brenner, T. A. Busey, J. S. Kwon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neural synchronization may have a critical role in the integration of information within and across cerebral structures. Synchronization, particularly at gamma range frequencies, is thought to be dependent on GABAergic interneurons, which may be disturbed in schizophrenia. We report that patients with schizophrenia show severe disruption of electroencephalogram (EEG) measures of neural synchronization to periodic auditory and visual stimulation. Both EEG power and phase synchronization to temporally modulated signals were affected in the beta or gamma frequency ranges. These findings are consistent with GABAergic dysregulation in schizophrenia, which disrupts neural synchronization. A deficit in neural synchronization at high firing frequencies could contribute to behavioral disturbances of perceptual and temporal integration observed in this disorder.

Original languageEnglish (US)
Pages (from-to)697-703
Number of pages7
JournalInternational Congress Series
Volume1232
Issue numberC
DOIs
StatePublished - Apr 1 2002

Fingerprint

Electroencephalography
Schizophrenia
Acoustic Stimulation
Photic Stimulation
Interneurons
Power (Psychology)

Keywords

  • EEG
  • Event-related potentials
  • Schizophrenia
  • Synchronization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

EEG synchronization deficits in schizophrenia spectrum disorders. / O'Donnell, Brian; Wilt, M. A.; Brenner, C. A.; Busey, T. A.; Kwon, J. S.

In: International Congress Series, Vol. 1232, No. C, 01.04.2002, p. 697-703.

Research output: Contribution to journalArticle

O'Donnell, Brian ; Wilt, M. A. ; Brenner, C. A. ; Busey, T. A. ; Kwon, J. S. / EEG synchronization deficits in schizophrenia spectrum disorders. In: International Congress Series. 2002 ; Vol. 1232, No. C. pp. 697-703.
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