EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder

Colleen A. Brenner, Olaf Sporns, Paul H. Lysaker, Brian F. O'Donnell

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Objective: The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. Method: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects. Results: The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude. Conclusions: Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.

Original languageEnglish (US)
Pages (from-to)2238-2240
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number12
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder'. Together they form a unique fingerprint.

Cite this