EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder

Colleen A. Brenner, Olaf Sporns, Paul H. Lysaker, Brian O'Donnell

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective: The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. Method: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects. Results: The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude. Conclusions: Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.

Original languageEnglish
Pages (from-to)2238-2240
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number12
DOIs
StatePublished - Dec 2003

Fingerprint

Schizotypal Personality Disorder
Psychotic Disorders
Electroencephalography
Schizophrenia
Evoked Potentials

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder. / Brenner, Colleen A.; Sporns, Olaf; Lysaker, Paul H.; O'Donnell, Brian.

In: American Journal of Psychiatry, Vol. 160, No. 12, 12.2003, p. 2238-2240.

Research output: Contribution to journalArticle

@article{b1cda35386764dd9bbb7aa630d26334f,
title = "EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder",
abstract = "Objective: The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. Method: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects. Results: The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude. Conclusions: Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.",
author = "Brenner, {Colleen A.} and Olaf Sporns and Lysaker, {Paul H.} and Brian O'Donnell",
year = "2003",
month = "12",
doi = "10.1176/appi.ajp.160.12.2238",
language = "English",
volume = "160",
pages = "2238--2240",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "12",

}

TY - JOUR

T1 - EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder

AU - Brenner, Colleen A.

AU - Sporns, Olaf

AU - Lysaker, Paul H.

AU - O'Donnell, Brian

PY - 2003/12

Y1 - 2003/12

N2 - Objective: The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. Method: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects. Results: The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude. Conclusions: Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.

AB - Objective: The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. Method: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects. Results: The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude. Conclusions: Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=10244234115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10244234115&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.160.12.2238

DO - 10.1176/appi.ajp.160.12.2238

M3 - Article

C2 - 14638599

AN - SCOPUS:10244234115

VL - 160

SP - 2238

EP - 2240

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 12

ER -