EEG topography in psychiatric diagnosis and drug treatment

J. G. Small, V. Milstein, J. J. Kellams, M. J. Miller, Orest Boyko, I. F. Small

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Brain surface activity monitoring (BSAM) of drug-free adult patients with mania, depression, and obsessive-compulsive disorder revealed no significant differences between them and age-sex-matched normal controls. Distinctive EEG changes were observed during treatment with carbamazepine and lithium in patients with affective disorders. Drug-free schizophrenics had more anterior slowing than did normals. Increased delta and theta activity was associated with neuroleptic therapy - most with clozapine and chlorpromazine and least with haloperidol. Higher left frontal alpha amplitudes were correlated with fewer negative symptoms of schizophrenia and better therapeutic response. Computerized tomographic ventricle-to-brain ratios exhibited robust positive correlations with beta-1 amplitudes that occurred exclusively during treatment with chlorpromazine. Alpha and beta-1 amplitudes were positively correlated with the BPRS anxiety depression factor in schizophrenic patients under all treatment conditions. Energy in theta and alpha bands was negatively related to the withdrawal-retardation factor during neuroleptic therapy. Future applications of EEG topography in clinical psychiatry appear promising for drug monitoring and therapeutic assessment.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalAnnals of Clinical Psychiatry
Volume1
Issue number1
StatePublished - 1989

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Mental Disorders
Electroencephalography
Pharmaceutical Preparations
Drug Monitoring
Chlorpromazine
Antipsychotic Agents
Therapeutics
Depression
Clozapine
Obsessive-Compulsive Disorder
Carbamazepine
Brain
Haloperidol
Mood Disorders
Bipolar Disorder
Lithium
Psychiatry
Schizophrenia
Anxiety

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

Cite this

Small, J. G., Milstein, V., Kellams, J. J., Miller, M. J., Boyko, O., & Small, I. F. (1989). EEG topography in psychiatric diagnosis and drug treatment. Annals of Clinical Psychiatry, 1(1), 7-17.

EEG topography in psychiatric diagnosis and drug treatment. / Small, J. G.; Milstein, V.; Kellams, J. J.; Miller, M. J.; Boyko, Orest; Small, I. F.

In: Annals of Clinical Psychiatry, Vol. 1, No. 1, 1989, p. 7-17.

Research output: Contribution to journalArticle

Small, JG, Milstein, V, Kellams, JJ, Miller, MJ, Boyko, O & Small, IF 1989, 'EEG topography in psychiatric diagnosis and drug treatment', Annals of Clinical Psychiatry, vol. 1, no. 1, pp. 7-17.
Small JG, Milstein V, Kellams JJ, Miller MJ, Boyko O, Small IF. EEG topography in psychiatric diagnosis and drug treatment. Annals of Clinical Psychiatry. 1989;1(1):7-17.
Small, J. G. ; Milstein, V. ; Kellams, J. J. ; Miller, M. J. ; Boyko, Orest ; Small, I. F. / EEG topography in psychiatric diagnosis and drug treatment. In: Annals of Clinical Psychiatry. 1989 ; Vol. 1, No. 1. pp. 7-17.
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