Brain surface activity monitoring (BSAM) of drug-free adult patients with mania, depression, and obsessive-compulsive disorder revealed no significant differences between them and age-sex-matched normal controls. Distinctive EEG changes were observed during treatment with carbamazepine and lithium in patients with affective disorders. Drug-free schizophrenics had more anterior slowing than did normals. Increased delta and theta activity was associated with neuroleptic therapy - most with clozapine and chlorpromazine and least with haloperidol. Higher left frontal alpha amplitudes were correlated with fewer negative symptoms of schizophrenia and better therapeutic response. Computerized tomographic ventricle-to-brain ratios exhibited robust positive correlations with beta-1 amplitudes that occurred exclusively during treatment with chlorpromazine. Alpha and beta-1 amplitudes were positively correlated with the BPRS anxiety depression factor in schizophrenic patients under all treatment conditions. Energy in theta and alpha bands was negatively related to the withdrawal-retardation factor during neuroleptic therapy. Future applications of EEG topography in clinical psychiatry appear promising for drug monitoring and therapeutic assessment.
ASJC Scopus subject areas
- Psychiatry and Mental health