EEG topography in psychiatric diagnosis and drug treatment

J. G. Small, V. Milstein, J. J. Kellams, M. J. Miller, O. B. Boyko, I. F. Small

Research output: Contribution to journalArticle

17 Scopus citations


Brain surface activity monitoring (BSAM) of drug-free adult patients with mania, depression, and obsessive-compulsive disorder revealed no significant differences between them and age-sex-matched normal controls. Distinctive EEG changes were observed during treatment with carbamazepine and lithium in patients with affective disorders. Drug-free schizophrenics had more anterior slowing than did normals. Increased delta and theta activity was associated with neuroleptic therapy - most with clozapine and chlorpromazine and least with haloperidol. Higher left frontal alpha amplitudes were correlated with fewer negative symptoms of schizophrenia and better therapeutic response. Computerized tomographic ventricle-to-brain ratios exhibited robust positive correlations with beta-1 amplitudes that occurred exclusively during treatment with chlorpromazine. Alpha and beta-1 amplitudes were positively correlated with the BPRS anxiety depression factor in schizophrenic patients under all treatment conditions. Energy in theta and alpha bands was negatively related to the withdrawal-retardation factor during neuroleptic therapy. Future applications of EEG topography in clinical psychiatry appear promising for drug monitoring and therapeutic assessment.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalAnnals of Clinical Psychiatry
Issue number1
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Small, J. G., Milstein, V., Kellams, J. J., Miller, M. J., Boyko, O. B., & Small, I. F. (1989). EEG topography in psychiatric diagnosis and drug treatment. Annals of Clinical Psychiatry, 1(1), 7-17.