Effect of acute metabolic stress on pituitary-adrenal axis activation in patients with schizophrenia

Igor Elman, Caleb M. Adler, Anil K. Malhotra, Christopher Bir, David Pickar, Alan Breier

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Objective: Although several lines of evidence suggest that stress plays a role in the course of schizophrenia, studies that have assessed stress- relevant neurobiological measures have not produced consistent results. The authors examined the effects of acute metabolic stress induced by 2-deoxy-D- glucose (2-DG) on pituitary-adrenal axis activation. Method: Thirteen patients with schizophrenia and 11 healthy comparison subjects were administered pharmacological doses of 2-DG (40 mg/kg). The subjects' arterial plasma was then assayed for levels of adrenocorticotropic hormone (ACTH) and cortisol. Results: 2-DG induced significant increases in the measured hormones in both groups, and ACTH elevations were significantly greater in patients with schizophrenia than in comparison subjects. Conclusions: Patients with schizophrenia have an exaggerated ACTH response to acute metabolic stress exposure.

Original languageEnglish (US)
Pages (from-to)979-981
Number of pages3
JournalAmerican Journal of Psychiatry
Volume155
Issue number7
StatePublished - 1998
Externally publishedYes

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Physiological Stress
Schizophrenia
Deoxyglucose
Adrenocorticotropic Hormone
Hydrocortisone
Healthy Volunteers
Hormones
Pharmacology

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Effect of acute metabolic stress on pituitary-adrenal axis activation in patients with schizophrenia. / Elman, Igor; Adler, Caleb M.; Malhotra, Anil K.; Bir, Christopher; Pickar, David; Breier, Alan.

In: American Journal of Psychiatry, Vol. 155, No. 7, 1998, p. 979-981.

Research output: Contribution to journalArticle

Elman, Igor ; Adler, Caleb M. ; Malhotra, Anil K. ; Bir, Christopher ; Pickar, David ; Breier, Alan. / Effect of acute metabolic stress on pituitary-adrenal axis activation in patients with schizophrenia. In: American Journal of Psychiatry. 1998 ; Vol. 155, No. 7. pp. 979-981.
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