Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neǐronakh krysy.

Translated title of the contribution: Effect of adenosine-5'-O-(beta, gamma-dichloromethane)triphosphate on ATP-activated currents in sensory neurons in rats

S. M. Marchenko, Alexander Obukhov, T. M. Volkova

Research output: Contribution to journalArticle

Abstract

The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.

Original languageUndefined/Unknown
Pages (from-to)29-30
Number of pages2
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume106
Issue number7
StatePublished - Jul 1988
Externally publishedYes

Fingerprint

Sensory Receptor Cells
Purinergic P2 Receptors
Neurons
Rats
Adenosine Triphosphate
Phosphates
Chemical activation
Derivatives
adenosine-5'-O-(beta,gamma-dichloromethane)triphosphate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neǐronakh krysy. / Marchenko, S. M.; Obukhov, Alexander; Volkova, T. M.

In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 106, No. 7, 07.1988, p. 29-30.

Research output: Contribution to journalArticle

@article{290350c16deb4fecb9abcad37aa3c432,
title = "Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neǐronakh krysy.",
abstract = "The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.",
author = "Marchenko, {S. M.} and Alexander Obukhov and Volkova, {T. M.}",
year = "1988",
month = "7",
language = "Undefined/Unknown",
volume = "106",
pages = "29--30",
journal = "Byulleten Eksperimentalnoi Biologii i Meditsiny",
issn = "0365-9615",
publisher = "Rossiiskaya Akademiya Meditsinskikh Nauk",
number = "7",

}

TY - JOUR

T1 - Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neǐronakh krysy.

AU - Marchenko, S. M.

AU - Obukhov, Alexander

AU - Volkova, T. M.

PY - 1988/7

Y1 - 1988/7

N2 - The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.

AB - The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.

UR - http://www.scopus.com/inward/record.url?scp=0024041691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024041691&partnerID=8YFLogxK

M3 - Article

VL - 106

SP - 29

EP - 30

JO - Byulleten Eksperimentalnoi Biologii i Meditsiny

JF - Byulleten Eksperimentalnoi Biologii i Meditsiny

SN - 0365-9615

IS - 7

ER -