Vliianie adenozin-5'-O-(beta, gamma-dikhlormetan)trifosfata na ATF-aktiviruimye toki v sensornykh neǐronakh krysy.

Translated title of the contribution: Effect of adenosine-5'-O-(beta, gamma-dichloromethane)triphosphate on ATP-activated currents in sensory neurons in rats

S. M. Marchenko, A. G. Obukhov, T. M. Volkova

Research output: Contribution to journalArticle

Abstract

The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.

Original languageRussian
Pages (from-to)29-30
Number of pages2
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume106
Issue number7
StatePublished - Jul 1 1988

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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