The action of beta,gamma-dihalogenmethane derivatives of ATP on ATP receptors has been studied in the sensory neurons of rats. beta,gamma-Dichloromethane-ATP and beta,gamma-dibromomethane-ATP are competitive blockers and beta,gamma-difluoromethane-ATP is a partial agonist of ATP receptors. At present, beta,gamma-dichloromethane-ATP is the most efficient of the known competitive blockers of these receptors (Ki = 2.10(-5) M). The data obtained confirm that beta- and gamma-phosphates of ATP play an important role in the activation of ATP receptors.
|Number of pages||2|
|Journal||Byulleten Eksperimentalnoi Biologii i Meditsiny|
|State||Published - Jul 1 1988|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)