Effect of aging on neurotransmitter receptor binding in rat and human brain

A. Maggi, M. J. Schmidt, Bernardino Ghetti, S. J. Enna

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

β-Adrenergic and GABA receptor binding were measured in brain areas of rats 3 to 24 months of age. While GABA receptor binding was not significantly different across age in any area, β-adrenergic receptor binding was significantly reduced in the cerebellum and brain stem, but not cerebral cortex, of 24-month-old animals. The loss in β-adrenergic receptor binding does not correlate in a temporal fashion with the reported decrease in norepinephrine-stimulated cyclic AMP accumulation in the cerebellum which occurs as early as 12 months of age. An age-related reduction in β-adrenergic binding was also noted in human cerebellar tissue obtained at autopsy, suggesting that the cerebellar dysfunction seen with aging may be related to a loss of cerebellar neurons which receive noradrenergic input.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalLife Sciences
Volume24
Issue number4
DOIs
StatePublished - Jan 22 1979

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Neurotransmitter Receptor
Adrenergic Receptors
Rats
Brain
GABA Receptors
Aging of materials
Cerebellum
Cerebellar Diseases
Cerebral Cortex
Cyclic AMP
Adrenergic Agents
Brain Stem
Neurons
Autopsy
Norepinephrine
Animals
Tissue

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of aging on neurotransmitter receptor binding in rat and human brain. / Maggi, A.; Schmidt, M. J.; Ghetti, Bernardino; Enna, S. J.

In: Life Sciences, Vol. 24, No. 4, 22.01.1979, p. 367-373.

Research output: Contribution to journalArticle

Maggi, A. ; Schmidt, M. J. ; Ghetti, Bernardino ; Enna, S. J. / Effect of aging on neurotransmitter receptor binding in rat and human brain. In: Life Sciences. 1979 ; Vol. 24, No. 4. pp. 367-373.
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