Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters

Maria Korre, Luiz Guilherme G Porto, Andrea Farioli, Justin Yang, David C. Christiani, Costas A. Christophi, David A. Lombardi, Richard Kovacs, Ronald Mastouri, Siddique Abbasi, Michael Steigner, Steven Moffatt, Denise Smith, Stefanos N. Kales

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Left ventricular (LV) mass is a strong predictor of cardiovascular disease (CVD) events; increased LV mass is common among US firefighters and plays a major role in firefighter sudden cardiac death. We aim to identify significant predictors of LV mass among firefighters. Cross-sectional study of 400 career male firefighters selected by an enriched randomization strategy. Weighted analyses were performed based on the total number of risk factors per subject with inverse probability weighting. LV mass was assessed by echocardiography (ECHO) and cardiac magnetic resonance, and normalized (indexed) for height. CVD risk parameters included vital signs at rest, body mass index (BMI)–defined obesity, obstructive sleep apnea risk, low cardiorespiratory fitness, and physical activity. Linear regression models were performed. In multivariate analyses, BMI was the only consistent significant independent predictor of LV mass indexes (all, p <0.001). A 1-unit decrease in BMI was associated with 1-unit (g/m1.7) reduction of LV mass/height1.7 after adjustment for age, obstructive sleep apnea risk, and cardiorespiratory fitness. In conclusion, after height-indexing ECHO-measured and cardiac magnetic resonance–measured LV mass, BMI was found to be a major driver of LV mass among firefighters. Our findings taken together with previous research suggest that reducing obesity will improve CVD risk profiles and decrease on-duty CVD and sudden cardiac death events in the fire service. Our results may also support targeted noninvasive screening for LV hypertrophy with ECHO among obese firefighters.

Original languageEnglish (US)
Pages (from-to)1769-1773
Number of pages5
JournalAmerican Journal of Cardiology
Volume118
Issue number11
DOIs
StatePublished - Dec 1 2016

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Firefighters
Body Mass Index
Cardiovascular Diseases
Echocardiography
Sudden Cardiac Death
Obstructive Sleep Apnea
Linear Models
Obesity
Vital Signs
Left Ventricular Hypertrophy
Random Allocation
Magnetic Resonance Spectroscopy
Multivariate Analysis
Cross-Sectional Studies
Exercise
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Korre, M., Porto, L. G. G., Farioli, A., Yang, J., Christiani, D. C., Christophi, C. A., ... Kales, S. N. (2016). Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters. American Journal of Cardiology, 118(11), 1769-1773. https://doi.org/10.1016/j.amjcard.2016.08.058

Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters. / Korre, Maria; Porto, Luiz Guilherme G; Farioli, Andrea; Yang, Justin; Christiani, David C.; Christophi, Costas A.; Lombardi, David A.; Kovacs, Richard; Mastouri, Ronald; Abbasi, Siddique; Steigner, Michael; Moffatt, Steven; Smith, Denise; Kales, Stefanos N.

In: American Journal of Cardiology, Vol. 118, No. 11, 01.12.2016, p. 1769-1773.

Research output: Contribution to journalArticle

Korre, M, Porto, LGG, Farioli, A, Yang, J, Christiani, DC, Christophi, CA, Lombardi, DA, Kovacs, R, Mastouri, R, Abbasi, S, Steigner, M, Moffatt, S, Smith, D & Kales, SN 2016, 'Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters', American Journal of Cardiology, vol. 118, no. 11, pp. 1769-1773. https://doi.org/10.1016/j.amjcard.2016.08.058
Korre M, Porto LGG, Farioli A, Yang J, Christiani DC, Christophi CA et al. Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters. American Journal of Cardiology. 2016 Dec 1;118(11):1769-1773. https://doi.org/10.1016/j.amjcard.2016.08.058
Korre, Maria ; Porto, Luiz Guilherme G ; Farioli, Andrea ; Yang, Justin ; Christiani, David C. ; Christophi, Costas A. ; Lombardi, David A. ; Kovacs, Richard ; Mastouri, Ronald ; Abbasi, Siddique ; Steigner, Michael ; Moffatt, Steven ; Smith, Denise ; Kales, Stefanos N. / Effect of Body Mass Index on Left Ventricular Mass in Career Male Firefighters. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 11. pp. 1769-1773.
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